Articles producció científica> Ciències Mèdiques Bàsiques

Components of a new gene family of ferroxidases involved in virulence are functionally specialized in fungal dimorphism

  • Identification data

    Identifier: imarina:5132651
    Handle: http://hdl.handle.net/20.500.11797/imarina5132651
  • Authors:

    Navarro-Mendoza MI, Pérez-Arques C, Murcia L, Martínez-García P, Lax C, Sanchis M, Capilla J, Nicolás FE, Garre V.
  • Others:

    Author, as appears in the article.: Navarro-Mendoza MI, Pérez-Arques C, Murcia L, Martínez-García P, Lax C, Sanchis M, Capilla J, Nicolás FE, Garre V.
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Capilla Luque, Javier / Sanchis Talón, Marta
    Keywords: Zygomycosis Siderophores Saccharomyces-cerevisiae Plasma-membrane Phylogenies Mucormycosis Epidemiology Antifungal Affinity iron permease Acquisition
    Abstract: Mucormycosis is an emerging angio-invasive infection caused by Mucorales that presents unacceptable mortality rates. Iron uptake has been related to mucormycosis, since serum iron availability predisposes the host to suffer this infection. In addition, iron uptake has been described as a limiting factor that determines virulence in other fungal infections, becoming a promising field to study virulence in Mucorales. Here, we identified a gene family of three ferroxidases in Mucor circinelloides, fet3a, fet3b and fet3c, which are overexpressed during infection in a mouse model for mucormycosis, and their expression in vitro is regulated by the availability of iron in the culture media and the dimorphic state. Thus, only fet3a is specifically expressed during yeast growth under anaerobic conditions, whereas fet3b and fet3c are specifically expressed in mycelium during aerobic growth. A deep genetic analysis revealed partially redundant roles of the three genes, showing a predominant role of fet3c, which is required for virulence during in vivo infections, and shared functional roles with fet3b and fet3c during vegetative growth in media with low iron concentration. These results represent the first described functional specialization of an iron uptake system during fungal dimorphism.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20452322
    Author's mail: marta.sanchis@urv.cat javier.capilla@urv.cat
    Author identifier: 0000-0001-7251-6792 0000-0002-0765-6403
    Record's date: 2023-02-18
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.nature.com/articles/s41598-018-26051-x
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Scientific Reports. 8 (1): 7660-
    APA: Navarro-Mendoza MI, Pérez-Arques C, Murcia L, Martínez-García P, Lax C, Sanchis M, Capilla J, Nicolás FE, Garre V. (2018). Components of a new gene family of ferroxidases involved in virulence are functionally specialized in fungal dimorphism. Scientific Reports, 8(1), 7660-. DOI: 10.1038/s41598-018-26051-x
    Article's DOI: 10.1038/s41598-018-26051-x
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Multidisciplinary,Multidisciplinary Sciences
    Zygomycosis
    Siderophores
    Saccharomyces-cerevisiae
    Plasma-membrane
    Phylogenies
    Mucormycosis
    Epidemiology
    Antifungal
    Affinity iron permease
    Acquisition
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Letras / linguística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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