Author, as appears in the article.: Sahebkar, Amirhossein; Sancho, Elena; Abello, David; Camps, Jordi; Joven, Jorge;

Department: Medicina i Cirurgia

URV's Author/s: Camps Andreu, Jorge / Joven Maried, Jorge

Keywords: Α-ketoglutarate Non-alcoholic fatty liver disease Diagnosis Ck18-f Biomarker ?-ketoglutarate non-alcoholic fatty liver disease diagnosis ck18-f biomarker

Abstract: © 2017 Wiley Periodicals, Inc. Currently, a liver biopsy remains the only reliable way to precisely diagnose non-alcoholic fatty liver disease (NAFLD) and establish the severity of liver injury, presence of fibrosis, and architecture remodeling. However, the cost and the intrinsic invasive procedure of a liver biopsy rules it out as a gold standard diagnostic test, and the imaging test are not the best choice due to the price, and currently is being refined. The lack of a biomarker of NAFLD pushes to develop this new line of research. The aim of the present systematic review is to clarify and update all the NAFLD biomarkers described in the literature until recently. We highlight α-ketoglutarate and CK18-F as currently the best potential biomarker of NAFLD. However, due to methodological differences, we propose the implementation of international, multicenter, multiethnic studies with larger population size, and biopsy proven NAFLD diagnosis to analyze and compare α-ketoglutarate and CK18-F as potential biomarkers of the silent evolution of NAFLD.

Thematic Areas: Química Physiology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Enfermagem Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Ciência da computação Cell biology Biotecnología Biodiversidade

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00219541

Author's mail: jorge.camps@urv.cat jorge.joven@urv.cat

Author identifier: 0000-0002-3165-3640 0000-0003-2749-4541

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.25779

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Cellular Physiology. 233 (2): 849-855

APA: Sahebkar, Amirhossein; Sancho, Elena; Abello, David; Camps, Jordi; Joven, Jorge; (2018). Novel circulating biomarkers for non-alcoholic fatty liver disease: A systematic review.. Journal Of Cellular Physiology, 233(2), 849-855. DOI: 10.1002/jcp.25779

Article's DOI: 10.1002/jcp.25779

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Journal Publications