Author, as appears in the article.: Dominguez-Molina, Beatriz; Ferrando-Martinez, Sara; Tarancon-Diez, Laura; Hernandez-Quero, Jose; Genebat, Miguel; Vidal, Francisco; Angeles Munoz-Fernandez, Ma; Leal, Manuel; Koup, Richard; Ruiz-Mateos, Ezequiel

Department: Medicina i Cirurgia

URV's Author/s: Vidal Marsal, Francisco

Keywords: Viral clearance T-cells Supercontrollers Spontaneous clearance Responses Pdcs Nonstructural protein-3 Nk Mutational escape Infection Hiv Hepatitis-c virus Hcv Dendritic cells Controllers Class-ii alleles Cd8(+) t-cells Cd4(+) t-cells spontaneous clearance pdcs nk hiv hcv controllers

Abstract: HIV-elite controllers are a minority group of HIV-infected patients with the ability to maintain undetectable HIV viremia for long time periods without antiretroviral treatment. A small group of HIV-controllers are also able to spontaneously clear the hepatitis C virus (HCV) whom we can refer to as supercontrollers. There are no studies that explore immune correlates looking for the mechanisms implicated in this extraordinary phenomenon. Herein, we have analyzed HCV- and HIV-specific T-cell responses, as well as T, dendritic and NK cell phenotypes. The higher HCV-specific CD4 T-cell polyfunctionality, together with a low activation and exhaustion T-cell phenotype was found in supercontrollers. In addition, the frequency of CD8 CD161high T-cells was related with HIV- and HCV-specific T-cells polyfunctionality. Interesting features regarding NK and plasmacytoid dendritic cells (pDCs) were found. The study of the supercontroller's immune response, subjects that spontaneously controls both chronic viral infections, could provide further insights into virus-specific responses needed to develop immunotherapeutic strategies in the setting of HIV cure or HCV vaccination.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Immunology and allergy Immunology Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Biodiversidade

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 16643224

Author's mail: francesc.vidal@urv.cat

Author identifier: 0000-0002-6692-6186

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.frontiersin.org/articles/10.3389/fimmu.2018.02897/full

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Frontiers In Immunology. 9 (2897): 2897-

APA: Dominguez-Molina, Beatriz; Ferrando-Martinez, Sara; Tarancon-Diez, Laura; Hernandez-Quero, Jose; Genebat, Miguel; Vidal, Francisco; Angeles Munoz-Fern (2018). Immune Correlates of Natural HIV Elite Control and Simultaneous HCV Clearance - Supercontrollers. Frontiers In Immunology, 9(2897), 2897-. DOI: 10.3389/fimmu.2018.02897

Article's DOI: 10.3389/fimmu.2018.02897

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Journal Publications