Author, as appears in the article.: Wandiyanto JV, Linklater D, Perera PGT, Orlowska A, Truong VK, Thissen H, Ghanaati S, Baulin V, Crawford RJ, Juodkazis S, Ivanova EP

Department: Enginyeria Química

URV's Author/s: Baulin, Vladimir

Keywords: Titanium Stem-cells Proliferation Pc12 cells Nanostructures Model Mechanobactericidal surfaces In-vivo Implants Growth Differentiation Behavior Bacteria Adhesion pc12 cells nanostructures mechanobactericidal surfaces

Abstract: Titanium is a biocompatible material that is frequently used for making implantable medical devices. Nanoengineering of the surface is the common method for increasing material biocompatibility, and while the nanostructured materials are well-known to represent attractive substrata for eukaryotic cells, very little information has been documented about the interaction between mammalian cells and bactericidal nanostructured surfaces. In this study, we investigated the effect of bactericidal titanium nanostructures on PC12 cell attachment and differentiation¿a cell line which has become a widely used in vitro model to study neuronal differentiation. The effects of the nanostructures on the cells were then compared to effects observed when the cells were placed in contact with non-structured titanium. It was found that bactericidal nanostructured surfaces enhanced the attachment of neuron-like cells. In addition, the PC12 cells were able to differentiate on nanostructured surfaces, while the cells on non-structured surfaces were not able to do so. These promising results demonstrate the potential application of bactericidal nanostructured surfaces in biomedical applications such as cochlear and neuronal implants. View

Thematic Areas: Química Odontología Medicina veterinaria Medicina i Materials science, multidisciplinary Materiais Interdisciplinar General materials science Engenharias iv Engenharias iii Engenharias ii Engenharias i Condensed matter physics Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Astronomia / física Arquitetura, urbanismo e design

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 19961944

Author's mail: vladimir.baulin@urv.cat

Author identifier: 0000-0003-2086-4271

Record's date: 2023-02-18

Journal volume: 11

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/1996-1944/11/4/605

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Materials. 11 (4): 605-

APA: Wandiyanto JV, Linklater D, Perera PGT, Orlowska A, Truong VK, Thissen H, Ghanaati S, Baulin V, Crawford RJ, Juodkazis S, Ivanova EP (2018). Pheochromocytoma (PC12) Cell Response on Mechanobactericidal Titanium Surfaces. Materials, 11(4), 605-. DOI: 10.3390/ma11040605

Article's DOI: 10.3390/ma11040605

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

First page: Article number 605

Publication Type: Journal Publications