Articles producció científica> Bioquímica i Biotecnologia

Potential Involvement of Peripheral Leptin/STAT3 Signaling in the Effects of Resveratrol and Its Metabolites on Reducing Body Fat Accumulation

  • Identification data

    Identifier: imarina:5132944
    Handle: http://hdl.handle.net/20.500.11797/imarina5132944
  • Authors:

    Ardid-Ruiz A, Ibars M, Mena P, Del Rio D, Muguerza B, Bladé C, Arola L, Aragonès G, Suárez M.
  • Others:

    Author, as appears in the article.: Ardid-Ruiz A, Ibars M, Mena P, Del Rio D, Muguerza B, Bladé C, Arola L, Aragonès G, Suárez M.
    Department: Bioquímica i Biotecnologia
    e-ISSN: 2072-6643
    URV's Author/s: Aragonès Bargalló, Gerard / Arola Ferrer, Luis Maria / IBARS SERRA, MARIA / Muguerza Marquínez, Maria Begoña / Suárez Recio, Manuel
    Keywords: Sirtuin Obesity Microbiota Metabolites Leptin resistance Cafeteria diet obesity microbiota metabolites leptin resistance cafeteria diet
    Abstract: Bioactive compounds such as polyphenols have increased in importance in recent years, and among them, resveratrol (3,5,4′-trihydroxy-trans-stilbene) has generated great interest as an anti-obesity agent. Recent investigations have highlighted the importance of leptin signaling in lipid metabolism in peripheral organs. The aims of this study were (1) to investigate whether resveratrol can reduce fat accumulation in peripheral tissues by increasing their leptin sensitivity and (2) to identify which resveratrol-derived circulating metabolites are potentially involved in these metabolic effects. Serum leptin levels and the leptin signaling pathway were assessed in diet-induced obese rats. Moreover, serum metabolites of resveratrol were studied by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MSn). The daily consumption of 200 mg/kg of resveratrol, but not doses of 50 and 100 mg/kg, reduced body weight and fat accumulation in obese rats and restored leptin sensitivity in the periphery. These effects were due to increases in sirtuin 1 activity in the liver, leptin receptors in muscle and protection against endoplasmic reticulum (ER)-stress in adipose tissue. In general, the resveratrol metabolites associated with these beneficial effects were derived from both phase II and microbiota metabolism, although only those derived from microbiota increased proportionally with the administered dose of resveratrol. In conclusion, resveratrol reversed leptin resistance caused by diet-induced obesity in peripheral organs using tissue-specific mechanisms.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20726643
    Author's mail: gerard.aragones@urv.cat begona.muguerza@urv.cat lluis.arola@urv.cat manuel.suarez@urv.cat
    Author identifier: 0000-0001-7384-8588 0000-0003-2767-1974 0000-0003-0122-8253
    Record's date: 2023-02-22
    Journal volume: 10
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/10/11/1757
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 10 (11):
    APA: Ardid-Ruiz A, Ibars M, Mena P, Del Rio D, Muguerza B, Bladé C, Arola L, Aragonès G, Suárez M. (2018). Potential Involvement of Peripheral Leptin/STAT3 Signaling in the Effects of Resveratrol and Its Metabolites on Reducing Body Fat Accumulation. Nutrients, 10(11), -. DOI: 10.3390/nu10111757
    Article's DOI: 10.3390/nu10111757
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Sirtuin
    Obesity
    Microbiota
    Metabolites
    Leptin resistance
    Cafeteria diet
    obesity
    microbiota
    metabolites
    leptin resistance
    cafeteria diet
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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