Author, as appears in the article.: Parra S, Lopez-Dupla M, Ibarretxe D, de Las Heras M, Amigó N, Català A, Benavent M, Garcés E, Navarro A, Castro A

Department: Medicina i Cirurgia

URV's Author/s: Castro Salomó, Antoni / Ibarretxe Gerediaga, Daiana / Parra Pérez, Sandra

Keywords: Vascular stiffness Risk Recommendations Intima-media thickness Independent predictor Dysfunction Disease-activity Damage Cholesterol Atherosclerosis

Abstract: Objective To investigate the metabolic and immunologic factors associated with the presence of central arterial stiffness as measured by the augmentation index (AIx). Methods We conducted a cross-sectional study of 69 female patients with systemic lupus erythematosus (SLE) compared with a control group of 34 healthy women. The anthropometrical variables, the vascular studies, and the analytic data were obtained the same day. The AIx was assessed by peripheral arterial tonometry. The analysis of lipoprotein populations was performed using nuclear magnetic resonance (NMR) spectroscopy. Results Arterial stiffness was increased in patients with SLE compared with control subjects (mean +/- SD 20.30 +/- 21.54% versus 10.84 +/- 11.51%; P = 0.0021). Values for the AIx were correlated with the Framingham risk score (r = 0.481, P < 0.001), carotid intima-media thickness (r = 0.503, P < 0.001), systolic blood pressure (r = 0.270, P < 0.001), and age (r = 0.365, P < 0.001). Patients receiving antimalarial drugs had a lower AIx (mean +/- SD 11.74 +/- 11.28% versus 24.97 +/- 20.63%; P = 0.024). The AIx was correlated with the atherogenic lipoproteins analyzed by NMR. The immunologic variables associated with the AIx were C4 (r = 0.259, P = 0.046) and IgM anti-beta(2)-glycoprotein I (IgM anti-beta(2)GPI) (r = 0.284, P = 0.284). In the multivariate analysis, age (beta = 0.347, 95% confidence interval [95% CI] 0.020-0.669, P = 0.035), IgM beta(2)GPI (beta = 0.321, 95% CI 0.024-0.618, P = 0.035) and small dense high-density lipoprotein (HDL) particles (beta = 1.288, 95% CI 0.246-2.329, P = 0.017) predicted the AIx. Conclusion SLE patients had increased arterial stiffness compared with healthy control subjects. Arterial stiffness was decreased in patients treated with antimalarial drugs. Age, IgM beta(2)GPI, and the number of small dense HDL particles predicted the AIx.

Thematic Areas: Saúde coletiva Rheumatology Rehabilitation Psicología Medicina iii Medicina ii Medicina i General medicine Farmacia Educação física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 2151464X

Author's mail: daiana.ibarretxe@urv.cat sandra.parra@urv.cat antoni.castro@urv.cat

Author identifier: 0000-0001-9363-6574 0000-0001-5441-6333

Last page: 125

Record's date: 2023-02-18

Journal volume: 71

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1002/acr.23594

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Arthritis Care & Research. 71 (1): 116-125

APA: Parra S, Lopez-Dupla M, Ibarretxe D, de Las Heras M, Amigó N, Català A, Benavent M, Garcés E, Navarro A, Castro A (2019). Patients with systemic lupus erythematosus show an increased arterial stiffness that is predicted by IgM anti-β[2] -Glycoprotein I and small dense high-density lipoprotein particles. Arthritis Care & Research, 71(1), 116-125. DOI: 10.1002/acr.23594

Article's DOI: 10.1002/acr.23594

Entity: Universitat Rovira i Virgili

Journal publication year: 2019

First page: 116

Publication Type: Journal Publications