Author, as appears in the article.: Martínez-Sellés M., Díez-Villanueva P., Álvarez-Gracía J., Ferrero-Gregori A., Vives-Borrás M., Worner F., Bardají A., Delgado J., Vázquez R., González-Juanatey J., Fernández-Aviles F., Cinca J.

Department: Medicina i Cirurgia

URV's Author/s: Bardají Ruiz, Alfredo

Keywords: Women Systolic dysfunction Sex Prognosis Pregnancy Predictor Outcomes Mortality Metaanalysis Left-ventricular contractility Heart failure Ejection fraction Association prognosis pregnancy heart failure

Abstract: Background Female sex is an independent predictor of better survival in patients with heart failure (HF), but the mechanism of this association is unknown. On the other hand, pregnancies have a strong influence on the cardiovascular system. Hypothesis Sex and previous gestations might have a prognostic impact on 1‐year mortality in patients admitted with HF. Methods We conducted an observational, prospective, consecutive, multicenter registry of 1831 patients (756 females [41.2%]) admitted with HF. Results Females had a more advanced age (75.2 ±11.4 vs 70.4 ±12.2 years), less ischemic heart disease (167 [25.3%] vs 446 [47.3%]), and higher left ventricular ejection fraction (52.0% ±16.6% vs 41.1% ±17.0%) than did men (all P values <0.001). During 1‐year follow‐up, 373 (20.4%) patients died (151 females and 222 males). Female sex was an independent predictor for survival (hazard ratio: 0.79, 95% confidence interval: 0.64-0.98, P = 0.03). In 504 women (65.9%), the exact number of previous pregnancies could be determined; 62 women (12.3%) had no previous pregnancies, 288 (57.1%) women had 1 or 2 pregnancies, and 154 women (30.6%) had ≥3 pregnancies. We found an association between the number of previous gestations and better survival (hazard ratio: 0.878, 95% confidence interval: 0.773-0.997, P = 0.045). Conclusions In patients admitted with HF, female sex and the number of previous pregnancies are independently associated with better 1‐year survival.

Thematic Areas: Saúde coletiva Nutrição Medicine (miscellaneous) Medicina ii Medicina i General medicine Farmacia Enfermagem Ciências biológicas ii Cardiology and cardiovascular medicine Cardiac & cardiovascular systems

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 01609289

Author's mail: alfredo.bardaji@urv.cat

Author identifier: 0000-0003-1900-6974

Record's date: 2023-02-22

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1002/clc.22979

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Clinical Cardiology. 41 (7): 924-930

APA: Martínez-Sellés M., Díez-Villanueva P., Álvarez-Gracía J., Ferrero-Gregori A., Vives-Borrás M., Worner F., Bardají A., Delgado J., Vázquez R., Gonzále (2018). Influence of sex and pregnancy on survival in patients admitted with heart failure: Data from a prospective multicenter registry. Clinical Cardiology, 41(7), 924-930. DOI: 10.1002/clc.22979

Article's DOI: 10.1002/clc.22979

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Journal Publications