Author, as appears in the article.: Taverner D, Paredes S, Ferré R, Masana L, Castro A, Vallvé JC

Department: Medicina i Cirurgia

URV's Author/s: FERRÉ VALLÈS, RAIMON / Masana Marín, Luis

Keywords: Systemic-lupus-erythematosus Risk-factors Reference values Pulse-wave velocity Noninvasive assessment Hemodynamics Determinants Cardiovascular-disease Blood-pressure Atherosclerosis

Abstract: We aimed to study arterial stiffness variables in patients with rheumatoid arthritis (RA), specifically considering their associations with path model mediation analysis. We examined arterial stiffness expressed by the pulse wave velocity (PVW), augmentation index (AIx), distensibility, and clinical and biochemical characteristics in a cohort of 214 RA patients. Variable associations were analysed using multivariate linear regression analysis. We also used path model mediation analysis for PWV variable. Our results indicate that age, systolic blood pressure (SBP), and body mass index (BMI) were significantly associated with PWV, and collectively accounted for 32% of PWV variability. The parallel mediation analysis showed that SBP and BMI accounted for 21% and 7% (a total of 28%) of the total effect of age on PWV, respectively, indicating a partial mediation effect. The associated variables with AIx were age and tender joint count, while those with distensibility were BMI and sex, overall accounting for 16.5% and 4.7% of the variation in AIx and distensibility, respectively. We observed no associations of arterial stiffness with inflammatory variables, disease activity and duration, or cholesterol levels. In conclusion, in our population of RA patients, age is the most important variable that determines the increase in PWV. We have also shown that a significant proportion of the negative effects of age on PWV occurs through increases in SBP and BMI. In our study, lipid and inflammation variables were not associated with an increase in arterial stiffness.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20452322

Author's mail: luis.masana@urv.cat

Author identifier: 0000-0002-0789-4954

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.nature.com/articles/s41598-019-41069-5

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Scientific Reports. 9 (1): 4543-4543

APA: Taverner D, Paredes S, Ferré R, Masana L, Castro A, Vallvé JC (2019). Assessment of arterial stiffness variables in patients with rheumatoid arthritis: A mediation analysis.. Scientific Reports, 9(1), 4543-4543. DOI: 10.1038/s41598-019-41069-5

Article's DOI: 10.1038/s41598-019-41069-5

Entity: Universitat Rovira i Virgili

Journal publication year: 2019

Publication Type: Journal Publications