Author, as appears in the article.: Girona J, Amigó N, Ibarretxe D, Plana N, Rodríguez-Borjabad C, Heras M, Ferré R, Gil M, Correig X, Masana L

Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia

e-ISSN: 1422-0067

URV's Author/s: Correig Blanchar, Francesc Xavier / FERRÉ VALLÈS, RAIMON / Girona Tell, Josefa / HERAS IBAÑEZ, MERCEDES / Masana Marín, Luis / Plana Gil, Núria

Keywords: Remnant cholesterol Ratio Normal-weight Myocardial-infarction Mortality Lipids Insulin-resistance Hdl triglycerides Hdl particle number Hdl cholesterol H-1-nmr Fenofibrate therapy Diabetes-mellitus Density-lipoprotein cholesterol Cardiovascular risk 1 h-nmr hdl triglycerides hdl particle number hdl cholesterol 1h-nmr

Abstract: While cholesterol content in high-density lipoproteins (HDLs) is a well-established inverse marker of cardiovascular risk, the importance of HDL-triglyceride (HDL-TG) concentration is not well known. We aim to examine plasma HDL-TG concentrations, assessed by 1H-NMR, in patients with metabolic diseases and their association with classical biomarkers. In this cross-sectional study, we included 502 patients with type 2 diabetes or metabolic syndrome attending the lipid unit of our University Hospital. The presence of arteriosclerotic plaques was assessed by ultrasonography. A complete lipoprotein profile was performed by 1H-NMR (Liposcale test). HDL-TG was strongly positively correlated with total triglycerides, glycerol, and fatty liver index, while a strong negative correlation was observed with HDL-cholesterol (HDL-C) and HDL-particle number (HDL-P). HDL-TG was associated with all triglyceride-rich lipoprotein parameters and had an opposite association with HDL-C and HDL-P. It was also significantly correlated with circulating cholesterol ester transfer protein (CETP). HDL-TG concentrations were higher as metabolic syndrome components increased. HDL-TG was also higher with worsening glucose metabolism. Patients with carotid plaques also showed higher HDL-TG. In contrast to HDL-C, HDL-TG is directly associated with metabolism and arteriosclerotic vascular alterations. HDL-TG should be considered a biomarker of metabolic and cardiovascular risk and could be a marker of HDL dysfunction.

Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14220067

Author's mail: xavier.correig@urv.cat josefa.girona@urv.cat nuria.plana@urv.cat luis.masana@urv.cat josefa.girona@urv.cat

Author identifier: 0000-0002-6902-3054 0000-0002-6267-8779 0000-0002-4231-7618 0000-0002-0789-4954 0000-0002-6267-8779

Record's date: 2023-02-26

Journal volume: 20

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/1422-0067/20/13/3151

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: International Journal Of Molecular Sciences. 20 (13):

APA: Girona J, Amigó N, Ibarretxe D, Plana N, Rodríguez-Borjabad C, Heras M, Ferré R, Gil M, Correig X, Masana L (2019). HDL Triglycerides: A New Marker of Metabolic and Cardiovascular Risk.. International Journal Of Molecular Sciences, 20(13), -. DOI: 10.3390/ijms20133151

Article's DOI: 10.3390/ijms20133151

Entity: Universitat Rovira i Virgili

Journal publication year: 2019

Publication Type: Journal Publications