Author, as appears in the article.: Cabré JJ; Mur T; Costa B; Barrio F; López-Moya C; Sagarra R; García-Barco M; Vizcaíno J; Bonaventura I; Ortiz N; Flores-Mateo G; Solà-Morales O; Catalan Diabetes Prevention Research Group

Department: Medicina i Cirurgia

e-ISSN: 2077-0383

URV's Author/s: Cabre Vila, Juan Jose

Keywords: Sudomotor reflex Screening Primary care Neuropathy Diabetes mellitus Dermal electrochemical conductance

Abstract: Diabetes mellitus (DM) is the leading cause of polyneuropathy in the Western world. Diabetic neuropathy (DNP) is the most common complication of diabetes and is of great clinical significance mainly due to the pain and the possibility of ulceration in the lower limbs. Early detection of neuropathy is essential in the medical management of this complication. Early unmyelinated C-fiber dysfunction is one of the typical findings of diabetic neuropathy and the first clinical manifestation of dysfunction indicating sudomotor eccrine gland impairment. In order to assess newly developed technology for the measurement of dermal electrochemical conductance (DEC), we analyzed the feasibility and effectiveness of DEC (quantitative expression of sudomotor reflex) as a screening test of DNP in primary health care centers. The study included 197 people (with type 2 diabetes, prediabetes and normal tolerance) who underwent all the protocol tests and electromyography (EMG). On comparing DEC with EMG as the gold standard, the area under the receiver operating characteristic (ROC) curve (AUC, area under the curve) was 0.58 in the whole sample, AUC = 0.65 in the diabetes population and AUC = 0.72 in prediabetes, being irrelevant in subjects without glucose disturbances (AUC = 0.47). Conclusions: In usual clinical practice, DEC is feasible, with moderate sensitivity but high specificity. It is also easy to use and interpret and requires little training, thereby making it a good screening test in populations with diabetes and prediabetes. It may also be useful in screening general populations at risk of neuropathy.

Thematic Areas: Medicine, general & internal Medicine (miscellaneous) Medicine (all)

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20770383

Author's mail: juanjose.cabre@urv.cat

Author identifier: 0000-0003-1082-6861

Record's date: 2023-02-18

Journal volume: 8

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2077-0383/8/5/598

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Clinical Medicine. 8 (5): 598-598

APA: Cabré JJ; Mur T; Costa B; Barrio F; López-Moya C; Sagarra R; García-Barco M; Vizcaíno J; Bonaventura I; Ortiz N; Flores-Mateo G; Solà-Morales O; Catal (2019). Feasibility and Effectiveness of Electrochemical Dermal Conductance Measurement for the Screening of Diabetic Neuropathy in Primary Care. Journal Of Clinical Medicine, 8(5), 598-598. DOI: 10.3390/jcm8050598

Article's DOI: 10.3390/jcm8050598

Entity: Universitat Rovira i Virgili

Journal publication year: 2019

First page: 598

Publication Type: Journal Publications