Articles producció científica> Bioquímica i Biotecnologia

Effects of a Mediterranean Eating Plan on the Need for Glucose-Lowering Medications in Participants With Type 2 Diabetes: A Subgroup Analysis of the PREDIMED Trial

  • Identification data

    Identifier: imarina:5779489
    Handle: http://hdl.handle.net/20.500.11797/imarina5779489
  • Authors:

    Javier Basterra-Gortari, F.
    Ruiz-Canela, Miguel
    Martinez-Gonzalez, Miguel A.
    Babio, Nancy
    Sorli, Jose V.
    Fito, Montserrat
    Ros, Emilio
    Gomez-Gracia, Enrique
    Fiol, Miquel
    Lapetra, Jose
    Estruch, Ramon
    Serra-Majem, Luis
    Pinto, Xavier
    Gonzalez, Jose I.
    Bullo, Monica
    Castaner, Olga
    Alonso-Gomez, Angel
    Forga, Luis
    Aros, Fernando
    PREDIMED Study Investigators
  • Others:

    Author, as appears in the article.: Javier Basterra-Gortari, F.; Ruiz-Canela, Miguel; Martinez-Gonzalez, Miguel A.; Babio, Nancy; Sorli, Jose V.; Fito, Montserrat; Ros, Emilio; Gomez-Gracia, Enrique; Fiol, Miquel; Lapetra, Jose; Estruch, Ramon; Serra-Majem, Luis; Pinto, Xavier; Gonzalez, Jose I.; Bullo, Monica; Castaner, Olga; Alonso-Gomez, Angel; Forga, Luis; Aros, Fernando;PREDIMED Study Investigators
    Department: Bioquímica i Biotecnologia Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Bulló Bonet, Mònica
    Keywords: Cardiovascular risk-factors therapy style diet outcomes metformin mellitus low-carbohydrate intervention insulin adherence
    Abstract: OBJECTIVE To examine the effects of two Mediterranean eating plans (Med-EatPlans) versus a low-fat eating plan on the need for glucose-lowering medications. RESEARCH DESIGN AND METHODS From the Prevencion con Dieta Mediterranea (PREDIMED) trial, we selected 3,230 participants with type 2 diabetes at baseline. These participants were randomly assigned to one of three eating plans: Med-EatPlan supplemented with extra-virgin olive oil (EVOO), Med-EatPlan supplemented with mixed nuts, or a low-fat eating plan (control). In a subgroup (15%), the allocation was done in small clusters instead of using individual randomization, and the clustering effect was taken into account in the statistical analysis. In multivariable time-to-event survival models, we assessed two outcomes: 1) introduction of the first glucose-lowering medication (oral or injectable) among participants on lifestyle management at enrollment and 2) insulin initiation. RESULTS After a median follow-up of 3.2 years, in multivariable analyses adjusting for baseline characteristics and propensity scores, the hazard ratios (HRs) of starting a first glucose-lowering medication were 0.78 (95% CI 0.62-0.98) for Med-EatPlan + EVOO and 0.89 (0.71-1.12) for Med-EatPlan + nuts, compared with the control eating plan. After a median follow-up of 5.1 years, the adjusted HRs of starting insulin treatment were 0.87 (0.68-1.11) for Med-EatPlan + EVOO and 0.89 (0.69-1.14) for Med-EatPlan + nuts compared with the control eating plan. CONCLUSIONS Among participants with type 2 diabetes, a Med-EatPlan + EVOO may delay the introduction of new-onset glucose-lowering medications. The Med-EatPlan did not result in a significantly lower need for insulin.
    Thematic Areas: Saúde coletiva Odontología Nutrição Medicina iii Medicina ii Medicina i Internal medicine Interdisciplinar General medicine Engenharias iv Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i Biotecnología Antropologia / arqueologia Advanced and specialized nursing
    ISSN: 01495992
    Author's mail: nancy.babio@urv.cat monica.bullo@urv.cat
    Author identifier: 0000-0003-3527-5277 0000-0002-0218-7046
    Record's date: 2023-02-18
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Diabetes Care. 42 (8): 1390-1397
    APA: Javier Basterra-Gortari, F.; Ruiz-Canela, Miguel; Martinez-Gonzalez, Miguel A.; Babio, Nancy; Sorli, Jose V.; Fito, Montserrat; Ros, Emilio; Gomez-Gra (2019). Effects of a Mediterranean Eating Plan on the Need for Glucose-Lowering Medications in Participants With Type 2 Diabetes: A Subgroup Analysis of the PREDIMED Trial. Diabetes Care, 42(8), 1390-1397. DOI: 10.2337/dc18-2475
    Article's DOI: 10.2337/dc18-2475
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2019
    Publication Type: Journal Publications
  • Keywords:

    Advanced and Specialized Nursing,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Internal Medicine
    Cardiovascular risk-factors
    therapy
    style diet
    outcomes
    metformin
    mellitus
    low-carbohydrate
    intervention
    insulin
    adherence
    Saúde coletiva
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Internal medicine
    Interdisciplinar
    General medicine
    Engenharias iv
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Antropologia / arqueologia
    Advanced and specialized nursing
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