Author, as appears in the article.: Fernández-Arroyo S, Hernández-Aguilera A, de Vries MA, Burggraaf B, van der Zwan E, Pouw N, Joven J, Cabezas MC

Department: Medicina i Cirurgia

e-ISSN: 2072-6643

URV's Author/s: Joven Maried, Jorge

Keywords: Sphingomyelin Receptor Postprandial inflammation Obesity Mitochondrial Metabolism Lipidomics Lipid absorption Inflammatory responses Glucose Fatty-acids Disease Differentiation Complement component-3 Cholecalciferol Arterial stiffness

Abstract: Abstract: Postprandial lipemia can lead to an accumulation of atherogenic lipoproteins in the circulation associated with systemic low-grade inflammation and an increased risk of cardiovascular disease. Lifestyle and pharmacological treatments are usually prescribed for prevention. Vitamin D3 (cholecalciferol), as an anti-atherogenic agent, is being taken into consideration due to its potential beneficial effects in lipid metabolism and its anti-inflammatory potency. To assess the effects of vitamin D3 in the postprandial lipid profile in obese, vitamin D-deficient women, a non-targeted lipidomics approach using liquid chromatography coupled to a quadrupole time-of flight mass spectrometer was used to identify and quantitate a wide-range of circulating lipid species, including diglycerides, lysophosphatidylcholines, phosphatidylcholines, phosphatidylethanolamines, sphingomyelins and triglycerides. The most important changes were found in plasmatic sphingomyelin levels, which experience a decrease after vitamin D3 intake. Our results suggest a turnover of sphingomyelins, probably due to an increased activity of neutral sphingomyelinases, and, therefore, with implications in the clearance of chylomicrons, LDL and VLDL, decreasing postprandial inflammation and macrophage adherence to endothelia, potentially improving cardiovascular disease risk.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20726643

Author's mail: jorge.joven@urv.cat

Author identifier: 0000-0003-2749-4541

Record's date: 2023-02-18

Journal volume: 11

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2072-6643/11/5/1194

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nutrients. 11 (5):

APA: Fernández-Arroyo S, Hernández-Aguilera A, de Vries MA, Burggraaf B, van der Zwan E, Pouw N, Joven J, Cabezas MC (2019). Effect of Vitamin D3 on the Postprandial Lipid Profile in Obese Patients: A Non-Targeted Lipidomics Study. Nutrients, 11(5), -. DOI: 10.3390/nu11051194

Article's DOI: 10.3390/nu11051194

Entity: Universitat Rovira i Virgili

Journal publication year: 2019

First page: 1194

Publication Type: Journal Publications