Author, as appears in the article.: Rosado-Sánchez I, Rodríguez-Gallego E, Peraire J, Viladés C, Herrero P, Fanjul F, Gutiérrez F, Bernal E, Pelazas R, Leal M, Veloso S, López-Dupla M, Blanco J, Vidal F, Pacheco YM, Rull A

Department: Medicina i Cirurgia

URV's Author/s: HERRERO GIL, POL / Peraire Forner, José Joaquin / RULL AIXA, ANNA / SIRVENT CALVERA, JUAN JOSÉ / Vidal Marsal, Francisco

Keywords: Risk Poor immune recovery Pipecolic acid Nmr-based lipoprotein profile Ms-based metabolomics Mortality Macrophages Lymphocytes Low cd4 counts Inflammation Hiv Differentiation Cd4+ t-cell turnover Cart Antiretroviral therapy Activation

Abstract: The immunological, biochemical and molecular mechanisms associated with poor immune recovery are far from known, and metabolomic profiling offers additional value to traditional soluble markers. Here, we present novel and relevant data that could contribute to better understanding of the molecular mechanisms preceding a discordant response and HIV progression under suppressive combined antiretroviral therapy (cART). Integrated data from nuclear magnetic resonance (NMR)-based lipoprotein profiles, mass spectrometry (MS)-based metabolomics and soluble plasma biomarkers help to build prognostic and immunological progression tools that enable the differentiation of HIV-infected subjects based on their immune recovery status after 96 weeks of suppressive cART. The metabolomic signature of ART-naïve HIV subjects with a subsequent late immune recovery is the expression of pro-inflammatory molecules and glutaminolysis, which is likely related to elevate T-cell turnover in these patients. The knowledge about how these metabolic pathways are interconnected and regulated provides new targets for future therapeutic interventions not only in HIV infection but also in other metabolic disorders such as human cancers where glutaminolysis is the alternative pathway for energy production in tumor cells to meet their requirement of rapid proliferation.© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Thematic Areas: Saúde coletiva Química Psicología Odontología Nutrição Medicine, research & experimental Medicine (miscellaneous) Medicine (all) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 01435221

Author's mail: joaquim.peraire@urv.cat francesc.vidal@urv.cat

Author identifier: 0000-0001-7808-5479 0000-0002-6692-6186

Record's date: 2023-05-21

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://portlandpress.com/clinsci/article-abstract/133/8/997/218855/Glutaminolysis-and-lipoproteins-are-key-factors-in?redirectedFrom=fulltext

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Clinical Science. 133 (8): 997-1010

APA: Rosado-Sánchez I, Rodríguez-Gallego E, Peraire J, Viladés C, Herrero P, Fanjul F, Gutiérrez F, Bernal E, Pelazas R, Leal M, Veloso S, López-Dupla M, B (2019). Glutaminolysis and lipoproteins are key factors in late immune recovery in successfully treated HIV-infected patients. Clinical Science, 133(8), 997-1010. DOI: 10.1042/CS20190111

Article's DOI: 10.1042/CS20190111

Entity: Universitat Rovira i Virgili

Journal publication year: 2019

Publication Type: Journal Publications