Author, as appears in the article.: Vázquez LI; Arija V; Aranda N; Aparicio E; Serrat N; Fargas F; Ruiz F; Pallejà M; Coronel P; Gimeno M; Basora J

Department: Ciències Mèdiques Bàsiques

e-ISSN: 2072-6643

URV's Author/s: Aparicio Llopis, Estefania / Aranda Pons, Núria / Arija Val, Maria Victoria / Basora Gallisa, Josep / Iglesias Vazquez, Lucia

Keywords: Stores Serum ferritin Risk Randomized controlled trial Questionnaire Prophylaxis Prevalence Pregnancy Outcomes Iron supplementation Iron stores Iron status Homeostasis Hfe gene Hemoglobin Hemoconcentration Consequences Anemia randomized controlled trial pregnancy iron supplementation iron stores iron status hfe gene hemoglobin

Abstract: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Iron deficiency (ID), anemia, iron deficiency anemia (IDA) and excess iron (hemoconcentration) harm maternal–fetal health. We evaluated the effectiveness of different doses of iron supplementation adjusted for the initial levels of hemoglobin (Hb) on maternal iron status and described some associated prenatal determinants. The ECLIPSES study included 791 women, randomized into two groups: Stratum 1 (Hb = 110–130g/L, received 40 or 80mg iron daily) and Stratum 2 (Hb > 130g/L, received 20 or 40mg iron daily). Clinical, biochemical, and genetic information was collected during pregnancy, as were lifestyle and sociodemographic characteristics. In Stratum 1, using 80 mg/d instead of 40 mg/d protected against ID on week 36. Only women with ID on week 12 benefited from the protection against anemia and IDA by increasing Hb levels. In Stratum 2, using 20 mg/d instead of 40 mg/d reduced the risk of hemoconcentration in women with initial serum ferritin (SF) ≥ 15 µg/L, while 40 mg/d improved SF levels on week 36 in women with ID in early pregnancy. Mutations in the HFE gene increased the risk of hemoconcentration. Iron supplementation should be adjusted to early pregnancy levels of Hb and iron stores. Mutations of the HFE gene should be evaluated in women with high Hb levels in early pregnancy.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20726643

Author's mail: estefania.aparicio@urv.cat josep.basora@urv.cat nuria.aranda@urv.cat lucia.iglesias@urv.cat victoria.arija@urv.cat josep.basora@urv.cat lucia.iglesias@urv.cat

Author identifier: 0000-0003-0542-0015 0000-0001-9708-747X 0000-0001-7131-4144 0000-0002-1758-0975 0000-0001-7131-4144

Record's date: 2023-02-18

Journal volume: 11

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2072-6643/11/10/2418

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nutrients. 11 (10):

APA: Vázquez LI; Arija V; Aranda N; Aparicio E; Serrat N; Fargas F; Ruiz F; Pallejà M; Coronel P; Gimeno M; Basora J (2019). The effectiveness of different doses of iron supplementation and the prenatal determinants of maternal iron status in pregnant spanish women: ECLIPSES study. Nutrients, 11(10), -. DOI: 10.3390/nu11102418

Article's DOI: 10.3390/nu11102418

Entity: Universitat Rovira i Virgili

Journal publication year: 2019

Publication Type: Journal Publications