Author, as appears in the article.: Rull, Anna; Camps, Jordi; Alonso-Villaverde, Carlos; Joven, Jorge;

Department: Medicina i Cirurgia

URV's Author/s: Camps Andreu, Jorge / Joven Maried, Jorge / RULL AIXA, ANNA

Keywords: Transcription factor T-cells Reduces atherosclerosis Macrophage infiltration Low-density-lipoprotein Human endothelial-cells Hepatic steatosis Gene-expression Endoplasmic-reticulum stress Adipose-tissue inflammation

Abstract: To maintain homeostasis under diverse metabolic conditions, it is necessary to coordinate nutrient-sensing pathways with the immune response. This coordination requires a complex relationship between cells, hormones, and cytokines in which inflammatory and metabolic pathways are convergent at multiple levels. Recruitment of macrophages to metabolically compromised tissue is a primary event in which chemokines play a crucial role. However, chemokines may also transmit cell signals that generate multiple responses, most unrelated to chemotaxis, that are involved in different biological processes. We have reviewed the evidence showing that monocyte chemoattractant protein-1 (MCP-1 or CCL2) may have a systemic role in the regulation of metabolism that sometimes is not necessarily linked to the traffic of inflammatory cells to susceptible tissues. Main topics cover the relationship betweenMCP-1/CCL2, insulin resistance, inflammation, obesity, and related metabolic disturbances.

Thematic Areas: Saúde coletiva Química Psicología Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Immunology Farmacia Engenharias iv Engenharias iii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Antropologia / arqueologia

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 0962-9351

Author's mail: jorge.camps@urv.cat jorge.joven@urv.cat

Author identifier: 0000-0002-3165-3640 0000-0003-2749-4541

Record's date: 2023-05-20

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.hindawi.com/journals/mi/2010/326580/

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Mediators Of Inflammation. 2010 (326580): 1244-1253

APA: Rull, Anna; Camps, Jordi; Alonso-Villaverde, Carlos; Joven, Jorge; (2010). Insulin Resistance, Inflammation, and Obesity: Role of Monocyte Chemoattractant Protein-1 (or CCL2) in the Regulation of Metabolism. Mediators Of Inflammation, 2010(326580), 1244-1253. DOI: 10.1155/2010/326580

Article's DOI: 10.1155/2010/326580

Entity: Universitat Rovira i Virgili

Journal publication year: 2010

Publication Type: Journal Publications