Author, as appears in the article.: Llaurado, Gemma; Amigo, Nuria; Cano, Albert; Ballesta, Silvia; Albert, Lara; Mazarico, Isabel; Fernandez-Veledo, Sonia; Pedro-Botet, Juan; Vendrell, Joan; Gonzalez-Clemente, Jose-Miguel;

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Fernandez Veledo, Sonia

Keywords: Type 1 diabetes mellitus Scientific statement Preclinical atherosclerosis Pittsburgh epidemiology Nuclear magnetic resonance spectroscopy Metabolic syndrome Low-density-lipoprotein Lipoprotein subclass profiles Ldl particle number Insulin-resistance Excess mortality Division working group Cardiovascular-disease Cardiovascular risk Arterial stiffness All-cause mortality preclinical atherosclerosis nuclear magnetic resonance spectroscopy lipoprotein subclass profiles cardiovascular risk arterial stiffness

Abstract: Background: Dyslipidemia has been associated with vascular complications of type 1 diabetes mellitus (T1DM). We examined the proton nuclear magnetic resonance (NMR)-assessed lipoprotein subclass profiles in subjects with T1DM compared with those of healthy subjects and assessed the potential relationship of these profiles with arterial stiffness. Methods: Eighty-four participants with T1DM of at least 10 years duration and no clinical cardiovascular disease (age: 35-65 years; 50% men) and 42 healthy participants were evaluated for: (1) clinical and anthropometric data (including classical cardiovascular risk factors), (2) insulin sensitivity by estimated glucose disposal rate, (3) microvascular complications, (4) NMR-assessed lipoprotein subclass profile, and (5) arterial stiffness (aortic pulse wave velocity). Results: Participants with T1DM had an apparently better conventional lipid profile than healthy participants, but with significant differences in NMR-assessed lipoprotein profiles such as higher triglyceride content of low-density lipoprotein (LDL) and high-density lipoprotein (HDL). In healthy participants, arterial stiffness was associated with NMR-based LDL subclasses. By contrast, in T1DM participants, arterial stiffness was independently associated mainly with NMR-based very-low-density lipoprotein (VLDL) subclasses: positively with total VLDL particles (and subclasses) and VLDL triglyceride content, and negatively with LDL and HDL particle sizes. These results were maintained after adjustments for classical cardiovascular risk factors. Conclusions: Subjects with T1DM, while having an apparently better conventional lipid profile than healthy controls, presented significant alterations in their NMR-assessed lipoprotein profile. The association between arterial stiffness and NMR-assessed lipoprotein profiles also differed in both groups. These results support a potential role of the identified differences in the residual cardiovascular risk in T1DM.

Thematic Areas: Medicine, general & internal Medicine (miscellaneous) Medicine (all)

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20770383

Author's mail: sonia.fernandez@urv.cat

Author identifier: 0000-0003-2906-3788

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2077-0383/8/11/1875

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Clinical Medicine. 8 (11):

APA: Llaurado, Gemma; Amigo, Nuria; Cano, Albert; Ballesta, Silvia; Albert, Lara; Mazarico, Isabel; Fernandez-Veledo, Sonia; Pedro-Botet, Juan; Vendrell, J (2019). Specific Nuclear Magnetic Resonance Lipoprotein Subclass Profiles and Central Arterial Stiffness in Type 1 Diabetes Mellitus: A Case Control Study. Journal Of Clinical Medicine, 8(11), -. DOI: 10.3390/jcm8111875

Article's DOI: 10.3390/jcm8111875

Entity: Universitat Rovira i Virgili

Journal publication year: 2019

Publication Type: Journal Publications