Author, as appears in the article.: Junqué E; Garcia S; Martínez M; Rovira J; Schuhmacher M; Grimalt J

Department: Enginyeria Química

URV's Author/s: Martínez Rodríguez, María Ángeles / Rovira Solano, Joaquim / Schuhmacher Ansuategui, Marta

Keywords: Umbilical cord serum Prenatal exposure Organochlorine compounds Mother-to-foetus pollutant transfer Maternal serum Human biomonitoring prenatal exposure organochlorine compounds mother-to-foetus pollutant transfer maternal serum human biomonitoring

Abstract: © 2019 Elsevier Inc. The concentrations of organochlorine compounds (OCs), including pentachlorobenzene, hexachlorobenzene (HCB), hexachlorocyclohexanes (α-, β-, γ- and δ-HCH), polychlorobiphenyls (PCBs 28, 52, 101, 118, 138, 153 and 180), DDT and metabolites, were measured in maternal serum samples collected at the first trimester of pregnancy, at delivery and in umbilical cord from a cohort of mother-newborn pairs from Tarragona (Spain) (n = 50), representing general population of a Mediterranean area from Southern Europe. The observed concentrations were generally low in comparison with previous studies in other world areas. Higher OC concentrations were observed in the maternal serum collected at delivery than in the first trimester and the cord blood concentrations were lower than the maternal levels. These results show for the first time a small but statistically significant increase in maternal venous concentration of OCs between the first trimester and delivery when measured in ng/ml. HCB, β-HCH and the PCB congeners in cord blood were significantly correlated with the concentrations of these compounds in maternal venous blood and the coefficients were stronger for the samples collected at delivery which was consistent with OC transfer from mother to foetus. In the case of DDT compounds, only 4,4′-DDT showed maternal-cord blood correlation which documented the low metabolic capacity of newborns for OC transformation, e.g. DDT into DDE. Maternal age was the most significant driver of the observed maternal venous OC concentrations in both periods, older ages involving higher concentrations. Higher body mass index was only significantly correlated with higher 4,4′-DDE concentrations in maternal venous blood and cord blood. In some cases, social class and education level were significantly correlated with OC concentrations, e.g. 4,4′-DDE in maternal venous blood from the first trimester and cord blood and PCB153 in maternal venous blood at delivery. In these cases, highest concentrations were found in the women with highest education level and most affluent social class. Comparison of the maternal OC concentrations of this cohort with those observed in 2002 in population of the same geographic area and age range shows decreases between two and ten times over this fourteen-year period.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 0013-9351

Author's mail: joaquim.rovira@urv.cat mangeles.martinez@urv.cat marta.schuhmacher@urv.cat

Author identifier: 0000-0003-4399-6138 0000-0001-8595-3772 0000-0003-4381-2490

Record's date: 2023-02-18

Journal volume: 182

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0013935119307911?via%3Dihub

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Environmental Research. 182 (108994): 108994-

APA: Junqué E; Garcia S; Martínez M; Rovira J; Schuhmacher M; Grimalt J (2020). Changes of organochlorine compound concentrations in maternal serum during pregnancy and comparison to serum cord blood composition. Environmental Research, 182(108994), 108994-. DOI: 10.1016/j.envres.2019.108994

Article's DOI: 10.1016/j.envres.2019.108994

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications