Author, as appears in the article.: Gutiérrez M; Santamaría R; Gómez-Reyes JF; Guzmán HM; Ávila-Román J; Motilva V; Talero E

Department: Bioquímica i Biotecnologia

URV's Author/s: Ávila Román, Francisco Javier

Keywords: Natural-products Microalgae Inflammation Gorgonian corals Eunicellin diterpenes Cytokines Cyclooxygenase-2 Chemistry Briareum Briarellins Asbestinins cytokines cyclooxygenase-2 briareum briarellins asbestinins

Abstract: Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract of Briareum asbestinum collected in Bocas del Toro, on the Caribbean side of Panama, led to the isolation of three new eunicellin-type diterpenes: briarellin T (1), asbestinin 27 (2), asbestinin 28 (3) and the previously described asbestinin 17 (4). The structures of the new compounds were determined by extensive NMR analyses and HRMS. Anti-inflammatory activity assays showed a significant reduction of the pro-inflammatory cytokines TNF-α, IL-6, IL-1β and IL-8 as well as a downregulation of COX-2 expression in LPS-stimulated THP-1 macrophages. These findings support the potential use of these marine compounds as therapeutic agents in the treatment of inflammatory diseases.

Thematic Areas: Zootecnia / recursos pesqueiros Química Pharmacology, toxicology and pharmaceutics (miscellaneous) Pharmacology & pharmacy Pharmaceutical science Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Geociências Farmacia Engenharias iii Engenharias ii Educação física Drug discovery Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Biotecnología Biodiversidade Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1660-3397

Author's mail: franciscojavier.avila@urv.cat

Author identifier: 0000-0001-9766-8178

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/1660-3397/18/2/84

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Marine Drugs. 18 (2):

APA: Gutiérrez M; Santamaría R; Gómez-Reyes JF; Guzmán HM; Ávila-Román J; Motilva V; Talero E (2020). New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum Asbestinum. Marine Drugs, 18(2), -. DOI: 10.3390/md18020084

Article's DOI: 10.3390/md18020084

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications