Author, as appears in the article.: Martín-González MZ; Palacios H; Rodríguez MA; Arola L; Aragonès G; Muguerza B

Department: Bioquímica i Biotecnologia

URV's Author/s: Aragonès Bargalló, Gerard / Arola Ferrer, Luis Maria / Muguerza Marquínez, Maria Begoña

Keywords: Supplementation Obesity Nafld Metabolomics Metabolic syndrome Liver Leptin Insulin-resistance Insulin resistance Inflammation High-fat Fish-oil Cla Chain amino-acids Blood-lipids Adiposity nafld metabolomics leptin insulin resistance cla

Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Conjugated linoleic acid (CLA) is a dietary supplement that has been shown to improve obesity. However, some authors have associated high doses of CLA supplementation with liver impairment and insulin resistance. The aim of this study was to assess whether the consumption of low doses of CLA maintained the beneficial effects on the main metabolic disturbances associated with metabolic syndrome (MetS) but prevented the occurrence of non-desirable outcomes associated with its consumption. Male Wistar rats, fed standard or cafeteria (CAF) diet for 12 weeks, were supplemented with three different low doses of CLA in the last three weeks. Both biochemical and H1 NMR-based metabolomics profiles were analysed in serum and liver. The consumption of 100 mg/kg CLA, but not doses of 200 and 300 mg/kg, ameliorated the increase in body weight gain as well as the serum concentrations of glucose, insulin, cholesterol, triglyceride, diglyceride, and total phospholipid induced by a CAF diet. In turn, CLA reverted the increase in lactate, alanine, and glucose concentrations in the liver of these animals, but enhanced hepatic cholesterol accumulation without any detrimental effect on liver function. In conclusion, a low dose of CLA corrected the adverse effects associated with MetS without compromising other metabolic parameters.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20726643

Author's mail: gerard.aragones@urv.cat begona.muguerza@urv.cat lluis.arola@urv.cat

Author identifier: 0000-0001-7384-8588 0000-0003-2767-1974

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2072-6643/12/2/408

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nutrients. 12 (2):

APA: Martín-González MZ; Palacios H; Rodríguez MA; Arola L; Aragonès G; Muguerza B (2020). Beneficial effects of a low-dose of conjugated linoleic acid on body weight gain and other cardiometabolic risk factors in cafeteria diet-fed rats. Nutrients, 12(2), -. DOI: 10.3390/nu12020408

Article's DOI: 10.3390/nu12020408

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications