Author, as appears in the article.: Palacios-Jordan H; Martín-González MZ; Suárez M; Aragonès G; Mugureza B; Rodríguez MA; Bladé C

Department: Bioquímica i Biotecnologia

URV's Author/s: Aragonès Bargalló, Gerard / BLADÉ SEGARRA, MARIA CINTA / Muguerza Marquínez, Maria Begoña / Suárez Recio, Manuel

Keywords: Secretion Phosphatidylcholine biosynthesis Obesity Metabolomics Low-density lipoprotein Liver Homocysteine s-methyltransferase Gender Fatty liver Expression Clock Circadian rhythms Choline Betaine metabolomics liver gender circadian rhythms

Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Circadian rhythms are ~24 h fluctuations of different biological processes that are regulated by the circadian clock system. They exert a major influence on most of the metabolism, such as the hepatic metabolism. This rhythmicity can be disrupted by obesogenic diets, fact that is considered to be a risk factor for the development of metabolic diseases. Nevertheless, obesogenic diets do not affect both genders in the same manner. We hypothesized that the circadian rhythms disruption of the hepatic metabolism, caused by obesogenic diets, is gender-dependent. Male and female Fischer 344 rats were fed either a standard diet or a cafeteria diet and sacrificed at two different moments, at zeitgeber 3 and 15. Only female rats maintained the circadian variations of the hepatic metabolism under a cafeteria diet. Most of those metabolites were related with the very low density lipoprotein (VLDL) synthesis, such as choline, betaine or phosphatidylcholine. Most of these metabolites were found to be increased at the beginning of the dark period. On the other hand, male animals did not show these time differences. These findings suggest that females might be more protected against the circadian disruption of the hepatic metabolism caused by a cafeteria diet through the increase of the VLDL synthesis at the beginning of the feeding time.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

ISSN: 20726643

Author's mail: gerard.aragones@urv.cat begona.muguerza@urv.cat manuel.suarez@urv.cat

Author identifier: 0000-0001-7384-8588 0000-0003-0122-8253

Record's date: 2023-02-22

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2072-6643/12/4/1085

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nutrients. 12 (4):

APA: Palacios-Jordan H; Martín-González MZ; Suárez M; Aragonès G; Mugureza B; Rodríguez MA; Bladé C (2020). The disruption of liver metabolic circadian rhythms by a cafeteria diet is sex-dependent in fischer 344 rats. Nutrients, 12(4), -. DOI: 10.3390/nu12041085

Article's DOI: 10.3390/nu12041085

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications