Articles producció científica> Medicina i Cirurgia

Effect of TNF-a genetic variants and CCR5 Delta 32 on the vulnerability to HIV-1 infection and disease progression in Caucasian Spaniards

  • Identification data

    Identifier: imarina:625163
    Handle: http://hdl.handle.net/20.500.11797/imarina625163
  • Authors:

    RICHART JURADO, CRISTOBAL MANUEL
    VELOSO ESTEBAN, SERGIO
    Veloso, Sergi
    Olona, Montserrat
    Garcia, Felipe
    Domingo, Pere
    Alonso-Villaverde, Carlos
    Broch, Montserrat
    Peraire, Joaquim
    Vilades, Consuelo
    Plana, Montserrat
    Pedrol, Enric
    Lopez-Dupla, Miguel
    Aguilar, Carmen
    Gutierrez, Mar
    Leon, Agathe
    Tasias, Mariona
    Gatell, Josep MA
    Richart, Cristobal
    VIDAL MARSAL, FRANCISCO
    Vidal, Francesc
  • Others:

    Author, as appears in the article.: RICHART JURADO, CRISTOBAL MANUEL; VELOSO ESTEBAN, SERGIO; Veloso, Sergi; Olona, Montserrat; Garcia, Felipe; Domingo, Pere; Alonso-Villaverde, Carlos; Broch, Montserrat; Peraire, Joaquim; Vilades, Consuelo; Plana, Montserrat; Pedrol, Enric; Lopez-Dupla, Miguel; Aguilar, Carmen; Gutierrez, Mar; Leon, Agathe; Tasias, Mariona; Gatell, Josep MA; Richart, Cristobal; VIDAL MARSAL, FRANCISCO; Vidal, Francesc
    Department: Medicina i Cirurgia
    URV's Author/s: Aguilar Crespillo, Carmen Isabel / Richart Jurado, Cristobal Manuel / SIRVENT CALVERA, JUAN JOSÉ / Veloso Esteban, Sergio / Vidal Marsal, Francisco
    Keywords: Type-1 Tumor-necrosis-factor Susceptibility Polymorphisms Linkage disequilibrium Human-immunodeficiency-virus Cohort Aids
    Abstract: Tumor necrosis factor alpha (TNF-alpha) is thought to be involved in the various immunogenetic events that influence HIV-1 infection.We aimed to determine whether carriage of the TNF-alpha-238G>A, -308G>A and -863 C>A gene promoter single nucleotide polymorphisms (SNP) and the CCR5 Delta 32 variant allele influence the risk of HIV-1 infection and disease progression in Caucasian Spaniards. The study group consisted of 423 individuals. Of these, 239 were uninfected (36 heavily exposed but uninfected [EU] and 203 healthy controls [HC]) and 184 were HIV-1-infected (109 typical progressors [TP] and 75 long-term nonprogressors [LTNP] of over 16 years' duration). TNF-alpha SNP and the CCR5 Delta 32 allele were assessed using PCR-RFLP and automatic sequencing analysis methods on white blood cell DNA. Genotype and allele frequencies were compared using the chi 2 test and the Fisher exact test. Haplotypes were compared by logistic regression analysis.The distribution of TNF-alpha-238G>A, -308G>A and -863 C>A genetic variants was non-significantly different in HIV-1-infected patients compared with uninfected individuals: -238G>A, p = 0.7 and p = 0.3; -308G>A, p = 0.05 and p = 0.07; -863 C>A, p = 0.7 and p = 0.4, for genotype and allele comparisons, respectively. Haplotype analyses, however, indicated that carriers of the haplotype H3 were significantly more common among uninfected subjects (p = 0.04). Among the infected patients, the distribution of the three TNF-alpha genetic variants assessed was non-significantly different between TP and LTNP: -238G>A, p = 0.35 and p = 0.7; -308G>A, p = 0.7 and p = 0.6: -863 C>A, p = 0.2 and p = 0.2, for genotype and allele comparisons, respectively. Haplotype analyses also indicated non-significant associations. Subanalyses in the LTNP subset indicated that the TNF-alpha-238A variant allele was significantly overrepresented in patients who spontaneously controlled plasma viremia compared with those who had a detectable plasma viral load (genotype comparisons, p = 0.02; allele comparisons, p = 0.03). The CCR5 Delta 32 distribution was non-significantly different in HIV-1-infected patients with respect to the uninfected population (p = 0.15 and p = 0.2 for genotype and allele comparisons, respectively) and in LTNP vs TP (p = 0.4 and p = 0.5 for genotype and allele comparisons, respectively).In our cohort of Caucasian Spaniards, TNF-alpha genetic variants could be involved in the vulnerability to HIV-1 infection. TNF-alpha genetic variants were unrelated to disease progression in infected subjects. The -238G>A SNP may modulate the control of viremia in LTNP. Carriage of the CCR5 Delta 32 variant allele had no effect on the risk of infection and disease progression.
    Thematic Areas: Saúde coletiva Química Odontología Nutrição Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Genetics (clinical) Genetics & heredity Genetics Farmacia Engenharias iv Engenharias iii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 14712350
    Author's mail: sergio.veloso@urv.cat cristobalmanuel.richart@urv.cat francesc.vidal@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat
    Author identifier: 0000-0003-0852-6739 0000-0002-6692-6186 0000-0002-4440-562X 0000-0002-4440-562X
    Record's date: 2023-02-22
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-11-63
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Bmc Medical Genetics. 11 (1): 63-
    APA: RICHART JURADO, CRISTOBAL MANUEL; VELOSO ESTEBAN, SERGIO; Veloso, Sergi; Olona, Montserrat; Garcia, Felipe; Domingo, Pere; Alonso-Villaverde, Carlos; (2010). Effect of TNF-a genetic variants and CCR5 Delta 32 on the vulnerability to HIV-1 infection and disease progression in Caucasian Spaniards. Bmc Medical Genetics, 11(1), 63-. DOI: 10.1186/1471-2350-11-63
    Article's DOI: 10.1186/1471-2350-11-63
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2010
    Publication Type: Journal Publications
  • Keywords:

    Genetics,Genetics & Heredity,Genetics (Clinical)
    Type-1
    Tumor-necrosis-factor
    Susceptibility
    Polymorphisms
    Linkage disequilibrium
    Human-immunodeficiency-virus
    Cohort
    Aids
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Matemática / probabilidade e estatística
    Interdisciplinar
    Genetics (clinical)
    Genetics & heredity
    Genetics
    Farmacia
    Engenharias iv
    Engenharias iii
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biodiversidade
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