Author, as appears in the article.: Malo AI, Rull A, Girona J, Domingo P, Fuertes-Martín R, Amigó N, Rodríguez-Borjabad C, Martínez-Micaelo N, Leal M, Peraire J, Correig X, Vidal F, Masana L

Department: Enginyeria Electrònica, Elèctrica i Automàtica Medicina i Cirurgia

URV's Author/s: Correig Blanchar, Francesc Xavier / Girona Tell, Josefa / Martínez Micaelo, Nieves Beatriz / Masana Marín, Luis / Peraire Forner, José Joaquin

Keywords: Therapy Responses Proton nuclear magnetic resonance (h-1-nmr) Proton nuclear magnetic resonance (1h-nmr) Mortality Mechanisms Inflammation Immunological responders Immune activation Hiv-1 Glycosylation Glycoprotein Disease Coagulation C-reactive protein Biomarkers

Abstract: Plasma glycoproteins are a composite biomarker of inflammation and can be detected by 1H-NMR. The aim of this study was to prospectively appraise the clinical value of plasma glycoproteins assessed by 1H-NMR in people living with HIV (PLWH). A total of 221 patients with HIV infection were recruited and studied at baseline and at 48 and 144 weeks. Patients were distributed into two groups according to baseline CD4+ T-cell number below or above 200 cells/µL. Patients with fewer than 200 cells/µL were distributed into the responders and nonresponders according to antiretroviral therapy (ART) response at 144 weeks. Glycoprotein concentrations were determined by 1H-NMR arising from the protein bond N-acetylglucosamine and N-acetylgalactosamine signals (GlycA); and N-acetylneuraminic acid signal (GlycB) associated with the sugar-protein bond concentration and aggregation state (shapes (height/width)). Basal glycoprotein concentrations were higher in patients with < 200 CD4+ T-cell/μL (Glyc A: 1040(917.9-1199.1) vs. 950.4(845.5-1050.9), p < 0.001, and Glyc B: 521(440.3-610.3) vs. 468.6(417.9-507.0) μ mol/L, p < 0.001) being reduced by ART. The height/width (H/W) ratio was the parameter showing a better association with this clinical status. Baseline glycoproteins predict the condition of responder/nonresponder. In this study, 1H-NMR glycoproteins provide novel insights to assess inflammation status and have prognostic value in PLWH.

Thematic Areas: Medicine, general & internal Medicine (miscellaneous) Medicine (all)

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20770383

Author's mail: xavier.correig@urv.cat josefa.girona@urv.cat neus.martinez@urv.cat joaquim.peraire@urv.cat luis.masana@urv.cat josefa.girona@urv.cat

Author identifier: 0000-0002-6902-3054 0000-0002-6267-8779 0000-0001-7808-5479 0000-0002-0789-4954 0000-0002-6267-8779

Record's date: 2023-02-26

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2077-0383/9/5/1344/htm

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Clinical Medicine. 9 (5):

APA: Malo AI, Rull A, Girona J, Domingo P, Fuertes-Martín R, Amigó N, Rodríguez-Borjabad C, Martínez-Micaelo N, Leal M, Peraire J, Correig X, Vidal F, Masa (2020). Glycoprotein Profile Assessed by 1H-NMR as a Global Inflammation Marker in Patients with HIV Infection. A Prospective Study. Journal Of Clinical Medicine, 9(5), -. DOI: 10.3390/jcm9051344

Article's DOI: 10.3390/jcm9051344

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications