Author, as appears in the article.: Rothwell, Joseph A; Urpi-Sarda, Mireia; Boto-Ordonez, Maria; Knox, Craig; Llorach, Rafael; Eisner, Roman; Cruz, Joseph; Neveu, Vanessa; Wishart, David; Manach, Claudine; Andres-Lacueva, Cristina; Scalbert, Augustin

Department: Bioquímica i Biotecnologia

URV's Author/s: Urpi Sarda, Mireia

Keywords: Risk Metaanalysis Foods Flavonoids Disease Consumption Cardiovascular risk Body-mass index Adults

Abstract: Phenol-Explorer, launched in 2009, is the only comprehensive web-based database on the content in foods of polyphenols, a major class of food bioactives that receive considerable attention due to their role in the prevention of diseases. Polyphenols are rarely absorbed and excreted in their ingested forms, but extensively metabolized in the body, and until now, no database has allowed the recall of identities and concentrations of polyphenol metabolites in biofluids after the consumption of polyphenol-rich sources. Knowledge of these metabolites is essential in the planning of experiments whose aim is to elucidate the effects of polyphenols on health. Release 2.0 is the first major update of the database, allowing the rapid retrieval of data on the biotransformations and pharmacokinetics of dietary polyphenols. Data on 375 polyphenol metabolites identified in urine and plasma were collected from 236 peer-reviewed publications on polyphenol metabolism in humans and experimental animals and added to the database by means of an extended relational design. Pharmacokinetic parameters have been collected and can be retrieved in both tabular and graphical form. The web interface has been enhanced and now allows the filtering of information according to various criteria. Phenol-Explorer 2.0, which will be periodically updated, should prove to be an even more useful and capable resource for polyphenol scientists because bioactivities and health effects of polyphenols are dependent on the nature and concentrations of metabolites reaching the target tissues. The Phenol-Explorer database is publicly available and can be found online at http://www.phenol-explorer.eu. Database URL: http://www.phenol-explorer.eu.

Thematic Areas: Saúde coletiva Química Odontología Medicine (miscellaneous) Medicina i Mathematical & computational biology Interdisciplinar Information systems Geociências General biochemistry,genetics and molecular biology General agricultural and biological sciences Engenharias iii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência da computação Biotecnología Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Agricultural and biological sciences (miscellaneous) Agricultural and biological sciences (all)

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 17580463

Author's mail: mireia.urpi@urv.cat

Record's date: 2022-07-23

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://academic.oup.com/database/article/doi/10.1093/database/bas031/436481

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Database-The Journal Of Biological Databases And Curation. 2012 bas031-

APA: Rothwell, Joseph A; Urpi-Sarda, Mireia; Boto-Ordonez, Maria; Knox, Craig; Llorach, Rafael; Eisner, Roman; Cruz, Joseph; Neveu, Vanessa; Wishart, David (2012). Phenol-Explorer 2.0: a major update of the Phenol-Explorer database integrating data on polyphenol metabolism and pharmacokinetics in humans and experimental animals. Database-The Journal Of Biological Databases And Curation, 2012(), bas031-. DOI: 10.1093/database/bas031

Article's DOI: 10.1093/database/bas031

Entity: Universitat Rovira i Virgili

Journal publication year: 2012

Publication Type: Journal Publications