Author, as appears in the article.: Cabré A; Lázaro I; Girona J; Manzanares J; Marimón F; Plana N; Heras M; Masana L

Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia

URV's Author/s: CABRÉ LLOBET, ANNA / Girona Tell, Josefa / HERAS IBAÑEZ, MERCEDES / LÁZARO LÓPEZ, IOLANDA / Masana Marín, Luis / Plana Gil, Núria

Keywords: Type 2 diabetes Obesity Metabolic syndrome Lipids Lipid-metabolism Insulin-resistance Insulin Human thp-1 macrophages Expression Disease Adipose-tissue Adiponectin Acid-binding protein

Abstract: The aim of this study was to evaluate the impact of adipocyte fatty acid binding protein 4 (FABP4) on the lipid profile in type 2 diabetic subjects. Plasma levels of FABP4 and adiponectin and an extensive lipid profile were analyzed in 169 type 2 diabetic subjects and 105 controls. Type 2 diabetic subjects were categorized according the presence of atherogenic dyslipidemia. Univariate statistical analyses, partial correlation tests, and binary logistic regression models were applied. In type 2 diabetic subjects, FABP4 was positively correlated with plasma triglycerides (P = 0.007), apolipoprotein C-III (apoC-III) (P = 0.009), and all the components of triglyceride-rich lipoproteins, including VLDL triglycerides (P = 0.002), VLDL-cholesterol (P = 0.001), and VLDL apoB (P = 0.001). FABP4 was inversely correlated with apoA-I (P = 0.038), HDL-cholesterol (P = 0.002), and HDL apoA-I (P = 0.010) in type 2 diabetic subjects. These correlations are not significantly affected by age, gender, body mass index, adiponectin, insulin, or any pharmacological treatment. The associations are even stronger when the FABP4/adiponectin ratio is considered. None of these associations were observed in controls. High FABP4 and low adiponectin levels are independent predictors of atherogenic dyslipidemia. In conclusion, FABP4 plasma concentrations hold strong potential for development as a clinical biomarker for atherogenic dyslipidemia, independent of obesity and insulin resistance, in type 2 diabetic subjects. Copyright © 2008 by the American Society for Biochemistry and Molecular Biology, Inc.

Thematic Areas: Zootecnia / recursos pesqueiros Química Medicina veterinaria Medicina iii Medicina ii Medicina i Farmacia Endocrinology Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cell biology Biodiversidade Biochemistry & molecular biology Biochemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00222275

Author's mail: josefa.girona@urv.cat nuria.plana@urv.cat luis.masana@urv.cat josefa.girona@urv.cat

Author identifier: 0000-0002-6267-8779 0000-0002-4231-7618 0000-0002-0789-4954 0000-0002-6267-8779

Record's date: 2023-02-26

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://pubmed.ncbi.nlm.nih.gov/18421072/

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Lipid Research. 49 (8): 1746-1751

APA: Cabré A; Lázaro I; Girona J; Manzanares J; Marimón F; Plana N; Heras M; Masana L (2008). Plasma fatty acid binding protein 4 is associated with atherogenic dyslipidemia in diabetes. Journal Of Lipid Research, 49(8), 1746-1751. DOI: 10.1194/jlr.M800102-JLR200

Article's DOI: 10.1194/jlr.M800102-JLR200

Entity: Universitat Rovira i Virgili

Journal publication year: 2008

Publication Type: Journal Publications