Author, as appears in the article.: Marsillach J; Camps J; Ferré N; Beltran R; Rull A; Mackness B; Mackness M; Joven J

Department: Medicina i Cirurgia

URV's Author/s: Beltrán Debón, Raúl Alejandro / Camps Andreu, Jorge / Ferre Pallas, Natalia / Joven Maried, Jorge / RULL AIXA, ANNA

Abstract: Background: Paraoxonase-1 (PON1) is an antioxidant enzyme synthesized by the liver. It protects against liver impairment and attenuates the production of the pro-inflammatory monocyte chemoattractant protein-1 (MCP-1). We investigated the relationships between hepatic PON1 and MCP-1 expression in rats with liver disease and explored the possible molecular mechanisms involved. Methods: CCl4 was administered for up to 12 weeks to induce liver damage. Serum and hepatic levels of PON1 and MCP-1, their gene and protein expression, nuclear transcription factors, and histological and biochemical markers of liver impairment were measured. Results: High levels of PON1 and MCP-1 expression were observed at 12th week in the hepatocytes surrounding the fibrous septa and inflammatory areas. CCl4-administered rats had an increased hepatic PON1 concentration that was related to decreased gene transcription and inhibited protein degradation. Decreased PON1 gene transcription was associated with PPARδ expression. These changes were accompanied by increased hepatic MCP-1 concentration and gene expression. There were significant direct relationships between hepatic PON1 and MCP-1 concentrations (P = 0.005) and between PON1 and the amount of activated stellate cells (P = 0.001). Conclusion: Our results from this experimental model suggest a hepato-protective role for PON1 against inflammation, fibrosis and liver disease mediated by MCP-1. © 2009 Marsillach et al; licensee BioMed Central Ltd.

Thematic Areas: Saúde coletiva Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Gastroenterology & hepatology Gastroenterology Farmacia Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Biodiversidade Antropologia / arqueologia

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1471-230X

Author's mail: jorge.camps@urv.cat raul.beltran@urv.cat natalia.ferre@urv.cat jorge.joven@urv.cat

Author identifier: 0000-0002-3165-3640 0000-0001-9691-1906 0000-0002-2838-1525 0000-0003-2749-4541

Record's date: 2023-02-19

Journal volume: 9

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-9-3

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Bmc Gastroenterology. 9 3-

APA: Marsillach J; Camps J; Ferré N; Beltran R; Rull A; Mackness B; Mackness M; Joven J (2009). Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease. Bmc Gastroenterology, 9(), 3-. DOI: 10.1186/1471-230X-9-3

Article's DOI: 10.1186/1471-230X-9-3

Entity: Universitat Rovira i Virgili

Journal publication year: 2009

Publication Type: Journal Publications