Author, as appears in the article.: Llauradó G; González-Clemente J; Maymó-Masip E; Subías D; Vendrell J; Chacón M

Department: Medicina i Cirurgia Bioquímica i Biotecnologia

URV's Author/s: Maymo Masip, Elsa / Rodríguez Chacón, Matilde / Vendrell Ortega, Juan José

Keywords: Stweak Soluble tweak Prediction Mortality Macrophages Inflammation Identification Disease Complications Arterial stiffness

Abstract: Objective: To test the usefulness of serum concentrations of tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and soluble scavenger receptor CD163 (sCD163) as markers of subtle inflammation in patients with type 1 diabetes mellitus (T1DM) without clinical cardiovascular (CV) disease and to evaluate their relationship with arterial stiffness (AS). Methods: Sixty-eight patients with T1DM and 68 age and sex-matched, healthy subjects were evaluated. Anthropometrical variables and CV risk factors were recorded. Serum concentrations of sTWEAK and sCD163 were measured. AS was assessed by aortic pulse wave velocity (aPWV). All statistical analyses were stratified by gender. Results: T1DM patients showed lower serum concentrations of sTWEAK (Men: 1636.5 (1146.3-3754.8) pg/mL vs. 765.9 (650.4-1097.1) pg/mL; p<0.001. Women: 1401.0 (788.0-2422.2) pg/mL vs. 830.1 (562.6-1175.9) pg/mL; p = 0.011) compared with their respective controls. Additionally, T1DM men had higher serum concentrations of sCD163 (285.0 (247.7-357.1) ng/mL vs. 224.8 (193.3-296.5) ng/mL; p = 0.012) compared with their respective controls. sTWEAK correlated negatively with aPWV in men (r = -0.443; p<0.001). However, this association disappeared after adjusting for potential confounders. In men, the best multiple linear regression model showed that the independent predictors of sTWEAK were T1DM and WHR (R2 = 0.640; p<0.001). In women, T1DM and SBP were the independent predictors for sTWEAK (R2 = 0.231; p = 0.001). Conclusion: sTWEAK is decreased in T1DM patients compared with age and sex-matched healthy subjects after adjusting for classic CV risk factors, although sTWEAK levels may be partially influenced by some of them. Additionally, T1DM men have higher serum concentrations of sCD163. These results point out an association between the inflammatory system and CV risk in T1DM. © 2012 Llauradó et al.

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licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 19326203

Author's mail: elsa.maymo@urv.cat matilde.rodriguez@urv.cat juanjose.vendrell@urv.cat

Author identifier: 0000-0002-9133-3120 0000-0002-6994-6115

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043919

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Plos One. 7 (8): e43919-

APA: Llauradó G; González-Clemente J; Maymó-Masip E; Subías D; Vendrell J; Chacón M (2012). Serum levels of TWEAK and scavenger receptor CD163 in type 1 diabetes mellitus: Relationship with cardiovascular risk factors. A case-control study. Plos One, 7(8), e43919-. DOI: 10.1371/journal.pone.0043919

Article's DOI: 10.1371/journal.pone.0043919

Entity: Universitat Rovira i Virgili

Journal publication year: 2012

Publication Type: Journal Publications