Author, as appears in the article.: Prats M; Font R; García-Ruiz C; Cabré C; Muñoz-Cortés M; Rosa Nogués M; Jariod M; Romeu M; Martínez-Vea A

Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia

URV's Author/s: Martínez Vea, Alberto / Muñoz Cortés, Mónica / Nogués Llort, Maria Rosa / Romeu Ferran, Marta

Keywords: Sucrose Risk Oxidative stress Markers Iron-deficiency anemia Intravenous iron Inflammation Hemodialysis-patients Ferric carboxymaltose Endothelial injury Dialysis patients Chronic kidney-disease Chronic kidney disease Adhesion molecules

Abstract: Background: Treatment with parenteral iron causes oxidative stress, inflammation and endothelial dysfunction. Ferric carboxymaltose (FCM) is a new preparation of non-dextran iron which, due to its pharmacokinetics and stability, may induce less toxicity than other iron molecules. The aim of this study was to analyse the effect of FCM on inflammation and adhesion molecules in chronic kidney disease (CKD). Methods: Forty-seven patients with predialysis CKD and irondeficiency anaemia received a single dose of FCM (15mg/kg, maximum dose 1 gram). At baseline and after 60 minutes (acute effect) and after 3 weeks and 3 months (sub-acute effect), we determined inflammatory markers: C-reactive protein (CRP), interleukin-6 (IL-6) and endothelial dysfunction: intercellular adhesion molecule (ICAM) and vascular adhesion molecule (VCAM). Results: Treatment with FCM was associated with a significant increase in haemoglobin levels: 10 (0.7) vs. 11.4 (1.3)g/dl, p<.0001. CRP, IL- 6, ICAM and VCAM levels did not correlate with baseline haemoglobin or ferritin levels and there was no relationship between changes in these markers and those of haemoglobin after administration of FCM. No significant, acute or subacute changes occurred in any of the inflammatory or endothelial markers studied. Statin therapy was associated with lower VCAM concentrations. Conclusions: Treatment with high doses of FCM in patients with predialysis CKD has no proinflammatory effect and does not alter levels of adhesion molecules ICAM and VCAM in this population. © 2013 Revista Nefrología. Órgano Oficial de la Sociedad Española de Nefrología.

Thematic Areas: Urology & nephrology Saúde coletiva Psicología Nephrology Medicine (miscellaneous) Medicine (all) Medicina ii Medicina i General medicine

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 02116995

Author's mail: monica.munoz@urv.cat alberto.martinez@urv.cat mariarosa.nogues@urv.cat marta.romeu@urv.cat

Author identifier: 0000-0002-0819-8096 0000-0003-4626-5672 0000-0002-2131-1858

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: http://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S0211-69952013000400009

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nefrologia. 33 (3): 355-361

APA: Prats M; Font R; García-Ruiz C; Cabré C; Muñoz-Cortés M; Rosa Nogués M; Jariod M; Romeu M; Martínez-Vea A (2013). Acute and sub-acute effect of ferric carboxymaltose on inflammation and adhesion molecules in patients with predialysis chronic renal failure. Nefrologia, 33(3), 355-361. DOI: 10.3265/Nefrologia.pre2013.Jan.11774

Article's DOI: 10.3265/Nefrologia.pre2013.Jan.11774

Entity: Universitat Rovira i Virgili

Journal publication year: 2013

Publication Type: Journal Publications