Author, as appears in the article.: García-Heredia A; Marsillach J; Rull A; Triguero I; Fort I; MacKness B; MacKness M; Shih D; Joven J; Camps J

Department: Medicina i Cirurgia

URV's Author/s: Camps Andreu, Jorge / Joven Maried, Jorge / RULL AIXA, ANNA

Abstract: We studied the influence of PON1 on metabolic alterations induced by oxidized LDL when incubated with endothelial cells. HUVEC cells were incubated with native LDL, oxidized LDL, oxidized LDL plus HDL from wild type mice, and oxidized LDL plus HDL from PON1-deficient mice. Results showed alterations in carbohydrate and phospholipid metabolism and increased apoptosis in cells incubated with oxidized LDL. These changes were partially prevented by wild type mouse HDL, but the effects were less effective with HDL from PON1-deficient mice. Our results suggest that PON1 may play a significant role in endothelial cell survival by protecting cells from alterations in the respiratory chain induced by oxidized LDL. These results extend current knowledge on the protective role of HDL and PON1 against oxidation and apoptosis in endothelial cells. © 2013 Anabel García-Heredia et al.

Thematic Areas: Saúde coletiva Química Psicología Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Immunology Farmacia Engenharias iv Engenharias iii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Antropologia / arqueologia

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 09629351

Author's mail: jorge.camps@urv.cat jorge.joven@urv.cat

Author identifier: 0000-0002-3165-3640 0000-0003-2749-4541

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.hindawi.com/journals/mi/2013/156053/

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Mediators Of Inflammation. 2013 156053-

APA: García-Heredia A; Marsillach J; Rull A; Triguero I; Fort I; MacKness B; MacKness M; Shih D; Joven J; Camps J (2013). Paraoxonase-1 inhibits oxidized low-density lipoprotein-induced metabolic alterations and apoptosis in endothelial cells: A nondirected metabolomic study. Mediators Of Inflammation, 2013(), 156053-. DOI: 10.1155/2013/156053

Article's DOI: 10.1155/2013/156053

Entity: Universitat Rovira i Virgili

Journal publication year: 2013

Publication Type: Journal Publications