Author, as appears in the article.: Ribas-Latre A; Del Bas JM; Baselga-Escudero L; Casanova E; Arola-Arnal A; Salvadó MJ; Arola L; Bladé C

Department: Bioquímica i Biotecnologia

URV's Author/s: Arola Arnal, Anna / Arola Ferrer, Luis Maria / BASELGA ESCUDERO, LAURA / BLADÉ SEGARRA, MARIA CINTA / CASANOVA VALLVÉ, ESTER / Ribas Latre, Aleix / Salvadó Rovira, Maria Josepa

Keywords: Xenohormesis Metabolomics Melatonin Flavonoids Bmal1 metabolomics melatonin flavonoids bmal1

Abstract: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Scope: Circadian rhythms allow organisms to anticipate and adapt to environmental changes, and food components can adjust internal rhythms. Proanthocyanidins improve cardiovascular risk factors that exhibit circadian oscillations. Therefore, the aim of the current study was to determine whether proanthocyanidins can modulate body rhythms. Methods and results: Male Wistar rats were orally gavaged with 250 mg grape seed proanthocyanidin extract (GSPE)/kg body weight at zeitgeber time (ZT) 0 (light on). Phenotypic biorhythm was evaluated by measuring the concentration of plasma melatonin and metabolites, using MNR-metabolomics, at several ZT. Remarkably, GSPE treatment maintained nocturnal melatonin levels at ZT3 and altered the oscillations of some metabolites in plasma. Quantification of expression of clock-core (Clock, Bmal1, Per2, Rorα, Rev-erbα) and clock-controlled (Nampt) genes in the hypothalamus by RT-PCR showed that this phenotypic alteration was concomitant with the modulation of the expression pattern of Bmal1 and Nampt. However, GSPE did not modulate the nocturnal expression of clock genes when administered at ZT12 (light off). Conclusion: PAs could have chronobiological properties, although their activity depends largely on the time of administration.

Research group: Grup de Recerca en Nutrigenòmica

Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 16134125

Author's mail: aleix.ribas@urv.cat lluis.arola@urv.cat mariajosepa.salvado@urv.cat anna.arola@urv.cat

Author identifier: 0000-0003-2767-1974 0000-0003-3883-3326 0000-0001-6529-1345

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201400571

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Molecular Nutrition & Food Research. 59 (5): 865-878

APA: Ribas-Latre A; Del Bas JM; Baselga-Escudero L; Casanova E; Arola-Arnal A; Salvadó MJ; Arola L; Bladé C (2015). Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats. Molecular Nutrition & Food Research, 59(5), 865-878. DOI: 10.1002/mnfr.201400571

Article's DOI: 10.1002/mnfr.201400571

Entity: Universitat Rovira i Virgili

Journal publication year: 2015

Publication Type: Journal Publications