Author, as appears in the article.: Tomàs J; Garcia N; Lanuza M; Santafé M; Tomàs M; Nadal L; Hurtado E; Simó A; Cilleros V

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Cilleros Mañé, Víctor / Garcia Sancho, Maria de les Neus / HURTADO CABALLERO, ERICA / Lanuza Escolano, María Angel / NADAL MAGRIÑÀ, LAURA / Santafé Martínez, Manuel / SIMÓ OLLÉ, ANNA / Tomás Ferré, José Maria / Tomas Marginet, Marta

Keywords: Voltage-dependent calcium channels Trkb Protein kinases Postnatal synapse elimination Pkc Muscarinic acetylcholine receptors Axonal competition Acetylcholine release trkb protein kinases postnatal synapse elimination pkc muscarinic acetylcholine receptors axonal competition acetylcholine release

Abstract: © 2017 Tomàs, Garcia, Lanuza, Santafé, Tomàs, Nadal, Hurtado, Simó and Cilleros. During the histogenesis of the nervous system a lush production of neurons, which establish an excessive number of synapses, is followed by a drop in both neurons and synaptic contacts as maturation proceeds. Hebbian competition between axons with different activities leads to the loss of roughly half of the neurons initially produced so connectivity is refined and specificity gained. The skeletal muscle fibers in the newborn neuromuscular junction (NMJ) are polyinnervated but by the end of the competition, 2 weeks later, the NMJ are innervated by only one axon. This peripheral synapse has long been used as a convenient model for synapse development. In the last few years, we have studied transmitter release and the local involvement of the presynaptic muscarinic acetylcholine autoreceptors (mAChR), adenosine autoreceptors (AR) and trophic factor receptors (TFR, for neurotrophins and trophic cytokines) during the development of NMJ and in the adult. This review article brings together previously published data and proposes a molecular background for developmental axonal competition and loss. At the end of the first week postnatal, these receptors modulate transmitter release in the various nerve terminals on polyinnervated NMJ and contribute to axonal competition and synapse elimination.

Thematic Areas: Neurosciences Molecular biology Medicina ii Ciências biológicas ii Cellular and molecular neuroscience

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 16625099

Author's mail: victor.cilleros@urv.cat marta.tomas@urv.cat manuel.santafe@urv.cat mariaangel.lanuza@urv.cat josepmaria.tomas@urv.cat victor.cilleros@urv.cat

Author identifier: 0000-0001-5690-9932 0000-0002-4151-1697 0000-0002-5462-5108 0000-0003-4795-4103 0000-0002-0406-0006 0000-0001-5690-9932

Record's date: 2023-09-02

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.frontiersin.org/articles/10.3389/fnmol.2017.00132/full

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Frontiers In Molecular Neuroscience. 10 132-

APA: Tomàs J; Garcia N; Lanuza M; Santafé M; Tomàs M; Nadal L; Hurtado E; Simó A; Cilleros V (2017). Presynaptic membrane receptors modulate ACh release, axonal competition and synapse elimination during neuromuscular junction development. Frontiers In Molecular Neuroscience, 10(), 132-. DOI: 10.3389/fnmol.2017.00132

Article's DOI: 10.3389/fnmol.2017.00132

Entity: Universitat Rovira i Virgili

Journal publication year: 2017

Publication Type: Journal Publications