Author, as appears in the article.: Olivares M; Walker AW; Capilla A; Benítez-Páez A; Palau F; Parkhill J; Castillejo G; Sanz Y

Department: Medicina i Cirurgia

URV's Author/s: Castillejo De Villasante, Gemma

Keywords: Intestinal microbiology Hla genes Celiac disease hla genes celiac disease

Abstract: © The Author(s). 2018. Background: To investigate whether alterations in the developing intestinal microbiota and immune markers precede celiac disease (CD) onset in infants at familial risk of developing the disease. Methods: A nested case-control study was carried out as part of a larger prospective cohort study, which included healthy full-term newborns (> 200) with at least one first relative with biopsy-verified CD. The present study includes cases of CD (n = 10) and the best-matched controls (n = 10) who did not develop the disease after 5-year follow-up. Fecal microbiota, assessed by high-throughput 16S rRNA gene amplicon sequencing, and immune parameters were profiled at 4 and 6 months of age and related to CD onset. Results: The microbiota of infants who remained healthy showed an increase in bacterial diversity over time, characterized by increases in Firmicutes families, but not those who developed CD. Infants who subsequently developed CD showed a significant reduction in sIgA levels over time, while those who remained healthy showed increases in TNF-α correlated to Bifidobacterium spp. An increased relative abundance of Bifidobacterium longum was associated with control children while increased proportions of Bifidobacterium breve and Enterococcus spp. were associated with CD development. Conclusion: The findings suggest that alterations in the early trajectory of gut microbiota in infants at CD risk could influence the immune maturation process and predispose to CD, although larger population studies are warranted to confirm this hypothesis.

Thematic Areas: Microbiology (medical) Microbiology Medicina i General medicine Ciências biológicas i

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 20492618

Author's mail: gemma.castillejo@urv.cat

Record's date: 2023-02-26

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-018-0415-6

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Microbiome. 6 (1): 36-

APA: Olivares M; Walker AW; Capilla A; Benítez-Páez A; Palau F; Parkhill J; Castillejo G; Sanz Y (2018). Gut microbiota trajectory in early life may predict development of celiac disease. Microbiome, 6(1), 36-. DOI: 10.1186/s40168-018-0415-6

Article's DOI: 10.1186/s40168-018-0415-6

Entity: Universitat Rovira i Virgili

Journal publication year: 2018

Publication Type: Journal Publications