Author, as appears in the article.: Ammendola M; Haponska M; Balik K; Modrakowska P; Matulewicz K; Kazmierski L; Lis A; Kozlowska J; Garcia-Valls R; Giamberini M; Bajek A; Tylkowski B

Department: Enginyeria Química

URV's Author/s: Garcia Valls, Ricard / Giamberini, Marta / Tylkowski, Bartosz

Keywords: Temperature Prevention Polyphenols Mechanisms In-vitro Chitosan Antioxidant activity

Abstract: © 2020, The Author(s). The growing interest of oncologists in natural compounds such as polyphenols and flavonoids is encouraging the development of innovative and efficient carriers for the delivery of those drugs. This study examines carboxymethyl chitosan-based microcapsules created by spray drying as a method for delivering biologically active compounds isolated from the Cistus herb. Effects of sterilization and encapsulation on the polyphenol and flavonoid content of Cistus extract were investigated to optimize the production process. Furthermore, in vitro studies were carried out to examine the anticancer properties of sterilized polyphenols and flavonoids on glioblastoma cells isolated from oncological patients. Acquired results show high anticancer potential towards glioblastoma as well as low cytotoxicity towards non-cancer cell lines by the substances in question. Steam sterilization is shown to affect the content of biologically active compounds the least. We demonstrate that the investigated form of drug encapsulation is both efficient and potentially possible to scale up from the viewpoint of the pharmaceutical industry.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 2045-2322

Author's mail: bartosz.tylkowski@urv.cat ricard.garcia@urv.cat marta.giamberini@urv.cat

Author identifier: 0000-0002-4163-0178 0000-0002-3945-0434 0000-0001-8278-3552

Record's date: 2023-02-19

Journal volume: 10

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.nature.com/articles/s41598-020-63444-3

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Scientific Reports. 10 (1): 6521-

APA: Ammendola M; Haponska M; Balik K; Modrakowska P; Matulewicz K; Kazmierski L; Lis A; Kozlowska J; Garcia-Valls R; Giamberini M; Bajek A; Tylkowski B (2020). Stability and anti-proliferative properties of biologically active compounds extracted from Cistus L. after sterilization treatments. Scientific Reports, 10(1), 6521-. DOI: 10.1038/s41598-020-63444-3

Article's DOI: 10.1038/s41598-020-63444-3

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications