Author, as appears in the article.: Masana L; Ibarretxe D; Plana N

Department: Medicina i Cirurgia

URV's Author/s: Ibarretxe Gerediaga, Daiana / Masana Marín, Luis / Plana Gil, Núria

Keywords: Very-low levels Statins Safety Pcsk9 inhibitors Metaanalysis Lipid-lowering combination therapy High-risk Fenofibrate therapy Ezetimibe Evolocumab Efficacy Density-lipoprotein cholesterol Cardiovascular prevention Cardiovascular outcomes Association pcsk9 inhibitors lipid-lowering combination therapy ezetimibe cardiovascular prevention

Abstract: © 2020, The Author(s). Purpose of Review: The aim of this report is to review the scientific evidence supporting that lipid lowering therapy (LLT), beyond statins, reduces cardiovascular risk; therefore, treatment strategies based on lipid-lowering drug combination should be implemented. Recent Findings: A strong scientific body of evidence supports the effect of statins on cardiovascular risk reduction. Recent trials using non-statin LLT, ezetimibe, and PCSK9 inhibitors have provide scientific evidence about their impact on cardiovascular prevention. Current clinical guidelines still recommend using high-intensity statin monotherapy before considering combination therapy. Summary: The causal effect of LDL-C on atherosclerosis is well established. Moreover, new RCT, meta-analysis, and Mendelian randomization data, support that the main determinant of risk reduction is the absolute LDL reduction regardless of LLT. Accordingly, the “high-intensity statin therapy” concept should be substituted by “high-intensity lipid lowering therapy.” Combination therapy must become the standard of care of hypercholesterolemia treatment.

Thematic Areas: Saúde coletiva Medicina ii Medicina i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 15343170

Author's mail: daiana.ibarretxe@urv.cat nuria.plana@urv.cat luis.masana@urv.cat

Author identifier: 0000-0002-4231-7618 0000-0002-0789-4954

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://link.springer.com/article/10.1007/s11886-020-01326-w

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Current Cardiology Reports. 22 (8): 66-

APA: Masana L; Ibarretxe D; Plana N (2020). Reasons Why Combination Therapy Should Be the New Standard of Care to Achieve the LDL-Cholesterol Targets: Lipid-lowering combination therapy. Current Cardiology Reports, 22(8), 66-. DOI: 10.1007/s11886-020-01326-w

Article's DOI: 10.1007/s11886-020-01326-w

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications