Articles producció científica> Ciències Mèdiques Bàsiques

Effects of Fish Oil and Grape Seed Extract Combination on Hepatic Endogenous Antioxidants and Bioactive Lipids in Diet-Induced Early Stages of Insulin Resistance in Rats

  • Identification data

    Identifier: imarina:6494788
    Handle: http://hdl.handle.net/20.500.11797/imarina6494788
  • Authors:

    Taltavull N
    Miralles-Pérez B
    Nogués MR
    Ramos-Romero S
    Méndez L
    Medina I
    Torres JL
    Romeu M
  • Others:

    Author, as appears in the article.: Taltavull N; Miralles-Pérez B; Nogués MR; Ramos-Romero S; Méndez L; Medina I; Torres JL; Romeu M
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Miralles Pérez, Bernat / Nogués Llort, Maria Rosa / Romeu Ferran, Marta / Taltavull Anglada, Núria
    Keywords: Steatosis Sphingomyelin synthase 2 Proanthocyanidins Polyunsaturated fatty-acids Polyphenols Oxidative stress Omega-3 pufa Omega-3 Metabolism Liver Glucose Diacylglycerol Ceramide Biological samples Antioxidants polyphenols omega-3 diacylglycerol ceramide antioxidants
    Abstract: Diacylglycerols (DAG) and ceramides have been suggested as early predictors of insulin resistance. This study was aimed to examine the combined effects of fish oil (FO) and grape seed extract (GSE) on hepatic endogenous antioxidants, DAG and ceramides in diet-induced early stages of insulin resistance. Thirty-five rats were fed one of the following diets: (1) a standard diet (STD group), (2) a high-fat high-sucrose diet (HFHS group), (3) an HFHS diet enriched with FO (FO group), (4) an HFHS diet enriched with GSE (GSE group) or (5) an HFHS diet enriched with FO and GSE (FO + GSE group). In the liver, endogenous antioxidants were measured using spectrophotometric and fluorometric techniques, and non-targeted lipidomics was conducted for the assessment of DAG and ceramides. After 24 weeks, the FO + GSE group showed increased glutathione peroxidase activity, as well as monounsaturated fatty acid and polyunsaturated fatty acid-containing DAG, and long-chain fatty acid-containing ceramides abundances compared to the STD group. The FO and GSE combination induced similar activation of the antioxidant system and bioactive lipid accumulation in the liver than the HFHS diet without supplementation. In addition, the FO and GSE combination increased the abundances of polyunsaturated fatty acid-containing DAG in the liver.
    Thematic Areas: Zootecnia / recursos pesqueiros Química Pharmacology, toxicology and pharmaceutics (miscellaneous) Pharmacology & pharmacy Pharmaceutical science Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Geociências Farmacia Engenharias iii Engenharias ii Educação física Drug discovery Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 16603397
    Author's mail: bernat.miralles@urv.cat nuria.taltavull@urv.cat mariarosa.nogues@urv.cat marta.romeu@urv.cat bernat.miralles@urv.cat
    Author identifier: 0000-0003-1294-7069 0000-0002-3340-2650 0000-0003-4626-5672 0000-0002-2131-1858 0000-0003-1294-7069
    Record's date: 2023-02-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1660-3397/18/6/318
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Marine Drugs. 18 (6):
    APA: Taltavull N; Miralles-Pérez B; Nogués MR; Ramos-Romero S; Méndez L; Medina I; Torres JL; Romeu M (2020). Effects of Fish Oil and Grape Seed Extract Combination on Hepatic Endogenous Antioxidants and Bioactive Lipids in Diet-Induced Early Stages of Insulin Resistance in Rats. Marine Drugs, 18(6), -. DOI: 10.3390/md18060318
    Article's DOI: 10.3390/md18060318
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Chemistry, Medicinal,Drug Discovery,Pharmaceutical Science,Pharmacology & Pharmacy,Pharmacology, Toxicology and Pharmaceutics (Miscellaneous)
    Steatosis
    Sphingomyelin synthase 2
    Proanthocyanidins
    Polyunsaturated fatty-acids
    Polyphenols
    Oxidative stress
    Omega-3 pufa
    Omega-3
    Metabolism
    Liver
    Glucose
    Diacylglycerol
    Ceramide
    Biological samples
    Antioxidants
    polyphenols
    omega-3
    diacylglycerol
    ceramide
    antioxidants
    Zootecnia / recursos pesqueiros
    Química
    Pharmacology, toxicology and pharmaceutics (miscellaneous)
    Pharmacology & pharmacy
    Pharmaceutical science
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Geociências
    Farmacia
    Engenharias iii
    Engenharias ii
    Educação física
    Drug discovery
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, medicinal
    Biotecnología
    Biodiversidade
    Astronomia / física
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