Author, as appears in the article.: Daimiel L; Micó V; Valls RM; Pedret A; Motilva MJ; Rubió L; Fitó M; Farrás M; Covas MI; Solá R; Ordovás JM

Department: Medicina i Cirurgia

URV's Author/s: Pedret Figuerola, Anna / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria

Keywords: Signature Risk Quality Polyphenols Micrornas Mediterranean diet Gene Extra virgin olive oil Expression Colon Cluster Cells Cardiovascular disease Biomarkers mediterranean diet extra virgin olive oil cardiovascular disease biomarkers

Abstract: This article is protected by copyright. All rights reserved. SCOPE: We aimed to investigate the postprandial modulation of cardiovascular-related microRNAs elicited by Extra Virgin Olive oil (EVOOs) containing different levels of own polyphenols METHODS AND RESULTS: Randomized, postprandial, parallel, double-blind study. 12 healthy participants consumed 30 mL of EVOO containing Low (L-EVOO; 250 mg total phenols/kg of oil), Medium (M-EVOO; 500 mg total phenols/kg of oil) and high (H-EVOO; 750 mg total phenols/kg of oil) polyphenol content to 6 h. Plasma microRNAs levels were analysed by Real-Time quantitative PCR. The results show that L-EVOO intake was associated with decreased let-7e-5p and miR-328a-3p levels and increased miR-17-5p and miR-20a-5p, concentrations. M-EVOO decreased plasma let-7e-5p and increased miR-17-5p, miR-20a-5p and miR-192-5p levels. Finally, H-EVOO decreased let-7e-5p, miR-10a-5p, miR-21-5p and miR-26b-5p levels. CONCLUSIONS: During the postprandial state, the levels of let-7e-5p decreased with EVOO regardless of polyphenol content suggesting a general response to the fatty acid composition of EVOO or/and the presence of at least 250 mg polyphenol/kg olive oil. Moreover, the miR-17-92 cluster increased by low and medium polyphenol content suggesting a role in fatty acid metabolism and nutrient sensing. Thus, modulation of circulating microRNAs levels could be a potential mechanism for the cardiovascular benefits associated with EVOO intake. This article is protected by copyright. All rights reserved.

Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 16134125

Author's mail: anna.pedret@urv.cat rosa.sola@urv.cat rosamaria.valls@urv.cat

Author identifier: 0000-0002-5327-932X 0000-0002-8359-235X 0000-0002-3351-0942

Record's date: 2023-02-27

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.202000049?casa_token=0IEwFxmocNIAAAAA%3AmEe_APPU2RO22IEtypvXjB3pCiTShWCRstIo59XPxtDRJI8NftZc25pjT9AFDhbVfMMVHWYegFG5HA

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Molecular Nutrition & Food Research. 64 (2000049): e2000049-

APA: Daimiel L; Micó V; Valls RM; Pedret A; Motilva MJ; Rubió L; Fitó M; Farrás M; Covas MI; Solá R; Ordovás JM (2020). Impact of Phenol-Enriched Virgin Olive Oils on the Postprandial Levels of Circulating microRNAs Related to Cardiovascular Disease. Molecular Nutrition & Food Research, 64(2000049), e2000049-. DOI: 10.1002/mnfr.202000049

Article's DOI: 10.1002/mnfr.202000049

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications