Author, as appears in the article.: Miguel Z Martín-González; Héctor Palacios-Jordan; Maria Ibars; Andrea Ardid-Ruiz; Albert Gibert-Ramos; Miguel A Rodríguez; Manuel Suárez; Begoña Muguerza; Gerard Aragonès

Department: Bioquímica i Biotecnologia

URV's Author/s: Muguerza Marquínez, Maria Begoña / Suárez Recio, Manuel

Keywords: Supplementation Resistance Protein Proanthocyanidins Obesity Multi-ingredient Liver Inhibition Induced obesity Hypothalamic sirt1 Fat Conjugated linoleic-acid Conjugated linoleic acid Bioactive peptides Anthocyanidins

Abstract: The use of a single family of dietary bioactive compounds has not been sufficient to manage highly regulated mechanisms such as body weight. Therefore, we aimed to evaluate the effect of a multifunctional ingredient (MIX) based on the co-administration of a low dose of conjugated linoleic acid with the protein hydrolysate from chicken feet, Hpp11, and a mixture of grape-seed proanthocyanidins and berry anthocyanins on body weight management in obese rats fed a cafeteria diet. The daily oral administration of the MIX for three weeks significantly reversed obesity and hyperleptinemia and increased energy expenditure and fat oxidation. In addition, animals administered the MIX exhibited greater hypothalamic activation of STAT3 in POMC-expressing neurons than non-supplemented animals. Our results strongly suggest that the co-administration of different bioactive compounds could be a promising strategy to complement the existing therapies against obesity and leptin resistance.

Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 17564646

Author's mail: begona.muguerza@urv.cat manuel.suarez@urv.cat

Author identifier: 0000-0001-7384-8588 0000-0003-0122-8253

Record's date: 2023-02-23

Journal volume: 73

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.sciencedirect.com/science/article/pii/S1756464620303650?via%3Dihub

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Functional Foods. 73 (104141):

APA: Miguel Z Martín-González; Héctor Palacios-Jordan; Maria Ibars; Andrea Ardid-Ruiz; Albert Gibert-Ramos; Miguel A Rodríguez; Manuel Suárez; Begoña Mugue (2020). A novel dietary multifunctional ingredient reduces body weight and improves leptin sensitivity in cafeteria diet-fed rats. Journal Of Functional Foods, 73(104141), -. DOI: 10.1016/j.jff.2020.104141

Article's DOI: 10.1016/j.jff.2020.104141

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications