Author, as appears in the article.: Faustmann G; Tiran B; Trajanoski S; Obermayer-Pietsch B; Gruber HJ; Ribalta J; Roob JM; Winklhofer-Roob BM

Department: Medicina i Cirurgia

URV's Author/s: Ribalta Vives, Josep

Keywords: Rela Peripheral blood mononuclear cells Pbmc P65 P50 Nuclear factor-kappa b Nf-κb N-6 fatty acids N-3 fatty acids Menstrual cycle Lipids Ldl-cholesterol Fatty acids Docosapentaenoic acid Cholesterol Canonical pathway C-rel Apolipoprotein b Apolipoprotein a-i Alpha-linolenic acid rela peripheral blood mononuclear cells pbmc p50 nuclear factor-kappa b nf-?b n-6 fatty acids n-3 fatty acids menstrual cycle lipids ldl-cholesterol fatty acids docosapentaenoic acid cholesterol canonical pathway c-rel apolipoprotein b apolipoprotein a-i alpha-linolenic acid

Abstract: © 2020 This study focused on a comprehensive analysis of the canonical activation pathway of the redox-sensitive transcription factor nuclear factor-kappa B (NF-κB) in peripheral blood mononuclear cells, addressing c-Rel, p65 and p50 activation in 28 women at early (T1) and late follicular (T2) and mid (T3) and late luteal (T4) phase of the menstrual cycle, and possible relations with fasting plasma lipids and fatty acids. For the first time, strong inverse relations of c-Rel with apolipoprotein B were observed across the cycle, while those with LDL cholesterol, triglycerides as well as saturated (SFA), particularly C14–C22 SFA, monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA) clustered at T2. In contrast, p65 was positively related to LDL cholesterol and total n-6 PUFA, while p50 did not show any relations. C-Rel was not directly associated with estradiol and progesterone, but data suggested an indirect C22:5n-3-mediated effect of progesterone. Strong positive relations between estradiol and individual SFA, MUFA and n-3 PUFA at T1 were confined to C18 fatty acids; C18:3n-3 was differentially associated with estradiol (positively) and progesterone (inversely). Given specific roles of c-Rel activation in immune tolerance, inhibition of c-Rel activation by higher plasma apolipoprotein B and individual fatty acid concentrations could have clinical implications for female fertility.

Thematic Areas: Zootecnia / recursos pesqueiros Química Psicología Physiology (medical) Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Endocrinology & metabolism Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 08915849

Author's mail: josep.ribalta@urv.cat

Author identifier: 0000-0002-8879-4719

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.sciencedirect.com/science/article/pii/S0891584920312077?via%3Dihub

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Free Radical Biology And Medicine. 160 488-500

APA: Faustmann G; Tiran B; Trajanoski S; Obermayer-Pietsch B; Gruber HJ; Ribalta J; Roob JM; Winklhofer-Roob BM (2020). Activation of nuclear factor-kappa B subunits c-Rel, p65 and p50 by plasma lipids and fatty acids across the menstrual cycle. Free Radical Biology And Medicine, 160(), 488-500. DOI: 10.1016/j.freeradbiomed.2020.08.012

Article's DOI: 10.1016/j.freeradbiomed.2020.08.012

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications