Articles producció científica> Medicina i Cirurgia

Systemic overexpression of C-C motif chemokine ligand 2 promotes metabolic dysregulation and premature death in mice with accelerated aging

  • Identification data

    Identifier: imarina:9138880
    Handle: http://hdl.handle.net/20.500.11797/imarina9138880
  • Authors:

    Luciano-Mateo F
    Cabré N
    Baiges-Gaya G
    Fernandez-Arroyo S
    Hernandez-Aguilera A
    Rodriguez-Tomas E
    Arenas M
    Camps J
    Menendez JA
    Joven J
  • Others:

    Author, as appears in the article.: Luciano-Mateo F; Cabré N; Baiges-Gaya G; Fernandez-Arroyo S; Hernandez-Aguilera A; Rodriguez-Tomas E; Arenas M; Camps J; Menendez JA; Joven J
    Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    URV's Author/s: Arenas Prat, Meritxell / FERNANDEZ ARROYO, SALVADOR / Joven Maried, Jorge
    Keywords: Progeria One-carbon metabolism Energy metabolism C-c motif chemokine ligand 2
    Abstract: © 2020 Mateo et al. Injection of tissues with senescent cells induces changes that mimic aging, and this process is delayed in mice engineered to eliminate senescent cells, which secrete proinflammatory cytokines, including C-C motif chemokine ligand 2 (Ccl2). Circulating levels of Ccl2 correlate with age, but the impact of Ccl2 on tissue homeostasis has not been established. We generated an experimental model by crossbreeding mice overexpressing Ccl2 with progeroid mice bearing a mutation in the lamin A (Lmna) gene. Wild-type animals and progeroid mice that do not overexpress Ccl2 were used as controls. Ccl2 overexpression decreased the lifespan of the progeroid mice and induced the dysregulation of glycolysis, the citric acid cycle and one-carbon metabolism in skeletal muscle, driving dynamic changes in energy metabolism and DNA methylation. This impact on cellular bioenergetics was associated with mitochondrial alterations and affected cellular metabolism, autophagy and protein synthesis through AMPK/mTOR pathways. The data revealed the ability of Ccl2 to promote death in mice with accelerated aging, which supports its putative use as a biomarker of an increased senescent cell burden and for the assessment of the efficacy of interventions aimed at extending healthy aging.
    Thematic Areas: Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Geriatrics & gerontology Ciências biológicas ii Ciências biológicas i Cell biology Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jorge.joven@urv.cat meritxell.arenas@urv.cat
    Author identifier: 0000-0003-2749-4541 0000-0003-0815-2570
    Record's date: 2023-02-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.aging-us.com/article/104154
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Aging-Us. 12 (20): 20001-20023
    APA: Luciano-Mateo F; Cabré N; Baiges-Gaya G; Fernandez-Arroyo S; Hernandez-Aguilera A; Rodriguez-Tomas E; Arenas M; Camps J; Menendez JA; Joven J (2020). Systemic overexpression of C-C motif chemokine ligand 2 promotes metabolic dysregulation and premature death in mice with accelerated aging. Aging-Us, 12(20), 20001-20023. DOI: 10.18632/aging.104154
    Article's DOI: 10.18632/aging.104154
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Cell Biology,Geriatrics & Gerontology
    Progeria
    One-carbon metabolism
    Energy metabolism
    C-c motif chemokine ligand 2
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Geriatrics & gerontology
    Ciências biológicas ii
    Ciências biológicas i
    Cell biology
    Biotecnología
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