Author, as appears in the article.: Castro-Barquero S; Ribó-Coll M; Lassale C; Tresserra-Rimbau A; Castañer O; Pintó X; Martínez-González MÁ; Sorlí JV; Salas-Salvadó J; Lapetra J; Gómez-Gracia E; Alonso-Gómez ÁM; Fiol M; Serra-Majem L; Sacanella E; Basterra-Gortari FJ; Portolés O; Babio N; Cofán M; Ros E; Estruch R; Hernáez Á

Department: Bioquímica i Biotecnologia

URV's Author/s: Babio Sánchez, Nancy Elvira / Salas Salvadó, Jorge

Keywords: Randomized controlled trials Prevention Platelet aggregation inhibitors Mediterranean diet 4-hydroxycoumarins

Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Our aim is to assess whether following a Mediterranean Diet (MedDiet) decreases the risk of initiating antithrombotic therapies and the cardiovascular risk associated with its use in older individuals at high cardiovascular risk. We evaluate whether participants of the PREvención con DIeta MEDiterránea (PREDIMED) study allocated to a MedDiet enriched in extra-virgin olive oil or nuts (versus a low-fat control intervention) disclose differences in the risk of initiation of: (1) vitamin K epoxide reductase inhibitors (acenocumarol/warfarin; n = 6772); (2) acetylsalicylic acid as antiplatelet agent (n = 5662); and (3) other antiplatelet drugs (cilostazol/clopidogrel/dipyridamole/ditazol/ticlopidine/triflusal; n = 6768). We also assess whether MedDiet modifies the association between the antithrombotic drug baseline use and incident cardiovascular events. The MedDiet intervention enriched with extra-virgin olive oil decreased the risk of initiating the use of vitamin K epoxide reductase inhibitors relative to control diet (HR: 0.68 [0.46–0.998]). Their use was also more strongly associated with an increased risk of cardiovascular disease in participants not allocated to MedDiet interventions (HRcontrol diet: 4.22 [1.92–9.30], HRMedDiets: 1.71 [0.83–3.52], p-interaction = 0.052). In conclusion, in an older population at high cardiovascular risk, following a MedDiet decreases the initiation of antithrombotic therapies and the risk of suffering major cardiovascular events among users of vitamin K epoxide reductase inhibitors.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: nancy.babio@urv.cat jordi.salas@urv.cat

Author identifier: 0000-0003-3527-5277 0000-0003-2700-7459

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2072-6643/12/12/3895

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nutrients. 12 (12): 1-14

APA: Castro-Barquero S; Ribó-Coll M; Lassale C; Tresserra-Rimbau A; Castañer O; Pintó X; Martínez-González MÁ; Sorlí JV; Salas-Salvadó J; Lapetra J; Gómez- (2020). Mediterranean diet decreases the initiation of use of vitamin k epoxide reductase inhibitors and their associated cardiovascular risk: A randomized controlled trial. Nutrients, 12(12), 1-14. DOI: 10.3390/nu12123895

Article's DOI: 10.3390/nu12123895

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications