Author, as appears in the article.: Guardia-Escote L; Blanco J; Basaure P; Biosca-Brull J; Verkaik-Schakel RN; Cabré M; Peris-Sampedro F; Pérez-Fernández C; Sánchez-Santed F; Plösch T; Domingo JL; Colomina MT

Department: Ciències Mèdiques Bàsiques Psicologia Bioquímica i Biotecnologia

URV's Author/s: BASAURE GARCÍA, PÍA ISABEL / Biosca Brull, Judit / Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia

Keywords: High-fat diet Feeding control Epigenetics Chlorpyrifos Apoe

Abstract: © 2020 by the authors. Li-censee MDPI, Basel, Switzerland. Developmental exposure to toxicants and diet can interact with an individual’s genetics and produce long-lasting metabolic adaptations. The different isoforms of the apolipoprotein E (APOE) are an important source of variability in metabolic disorders and influence the response to the pesticide chlorpyrifos (CPF). We aimed to study the epigenetic regulation on feeding control genes and the influence of postnatal CPF exposure, APOE genotype, and sex, and how these modifications impact on the metabolic response to a high-fat diet (HFD). Both male and female apoE3-and apoE4-TR mice were exposed to CPF on postnatal days 10–15. The DNA methylation pattern of proopiomelanocortin, neuropeptide Y, leptin receptor, and insulin-like growth factor 2 was studied in the hypothalamus. At adulthood, the mice were given a HFD for eight weeks. The results highlight the importance of sex in the epigenetic regulation and the implication of CPF treatment and APOE genotype. The body weight progression exhibited sex-dimorphic differences, apoE4-TR males being the most susceptible to the effects induced by CPF and HFD. Overall, these results underscore the pivotal role of sex, APOE genotype, and developmental exposure to CPF on subsequent metabolic disturbances later in life and show that sex is a key variable in epigenetic regulation.

Thematic Areas: Zootecnia / recursos pesqueiros Serviço social Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Pollution Odontología Nutrição Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Health, toxicology and mutagenesis Geografía Geociências Farmacia Environmental studies Environmental sciences Ensino Engenharias ii Engenharias i Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Biotecnología Biodiversidade Astronomia / física Administração pública e de empresas, ciências contábeis e turismo

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: judit.biosca@urv.cat jordi.blanco@urv.cat mariateresa.colomina@urv.cat joseluis.domingo@urv.cat judit.biosca@urv.cat maria.cabre@urv.cat

Author identifier: 0000-0001-8016-0984 0000-0002-5619-4874 0000-0001-6647-9470 0000-0003-4124-8603

Record's date: 2023-08-05

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/1660-4601/18/1/184

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: International Journal Of Environmental Research And Public Health. 18 (1): 1-17

APA: Guardia-Escote L; Blanco J; Basaure P; Biosca-Brull J; Verkaik-Schakel RN; Cabré M; Peris-Sampedro F; Pérez-Fernández C; Sánchez-Santed F; Plösch T; D (2021). Sex and exposure to postnatal chlorpyrifos influence the epigenetics of feeding-related genes in a transgenic apoe mouse model: Long-term implications on body weight after a high-fat diet. International Journal Of Environmental Research And Public Health, 18(1), 1-17. DOI: 10.3390/ijerph18010184

Article's DOI: 10.3390/ijerph18010184

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications