Author, as appears in the article.: Monika Haponska, Paulina Modrakowska, Karolina Balik, Anna Bajek, Anne Coloigner, Bartosz Tylkowski *, Marta Giamberini *

Department: Enginyeria Química

URV's Author/s: Giamberini, Marta / Tylkowski, Bartosz

Keywords: Tissue regeneration Scanning electron microscopy Radiation dermatitis Plaster Natural complexity Medical plaster Environmental scanning electron microscopies (esem) Contact angle Coatings Chitosan matrices Chitosan Cellular viability Carboxymethyl chitosan Biomechanics Biologic active compounds Active principles Active compounds

Abstract: Our investigation was focused on the preparation and characterization of novel plasters based on Carboxymethyl Chitosan derivative (CMC), to be used for the treatment of radiation dermatitis with Biologic Active Compounds (BACs) in a moist wound-healing environment. After performing the extraction and characterization of BACs from Cistus L., we optimized the BACs/CMC solution for subsequent plaster preparation. Then, plasters were prepared by dip-coating with a different number of layers, and we characterized them by Environmental Scanning Electron Microscopy (ESEM), Contact Angle (CA) and release tests in water for 24 h. Taking into account the flexibility of the plasters and the amount of released BACs after 24 h, the sample obtained after two dip-coating steps (2La) appeared promising in regard to comfortable mechanical properties and active principles administration. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test performed on keratinocytes cultured in standard medium shows that cells treated with released extract from 2La start to proliferate, extend cellular viability and form colonies typical for epidermal cells.

Thematic Areas: Physics, condensed matter Physics, applied Metallurgy & metallurgical engineering Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) Condensed matter physics Chemistry, physical

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 1996-1944

Author's mail: bartosz.tylkowski@urv.cat marta.giamberini@urv.cat

Author identifier: 0000-0002-4163-0178 0000-0001-8278-3552

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/1996-1944/14/3/582

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Materials. 14 (3): 582-13

APA: Monika Haponska, Paulina Modrakowska, Karolina Balik, Anna Bajek, Anne Coloigner, Bartosz Tylkowski *, Marta Giamberini * (2021). Medical plaster enhancement by coating with Cistus L. extracts within a chitosan matrix: from natural complexity to health care simplicity. Materials, 14(3), 582-13. DOI: 10.3390/ma14030582

Article's DOI: 10.3390/ma14030582

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications