Articles producció científica> Bioquímica i Biotecnologia

Ace inhibitory and antihypertensive activities of wine lees and relationship among bioactivity and phenolic profile

  • Identification data

    Identifier: imarina:9162278
    Handle: http://hdl.handle.net/20.500.11797/imarina9162278
  • Authors:

    López-Fernández-sobrino R
    Soliz-Rueda JR
    Margalef M
    Arola-Arnal A
    Suárez M
    Bravo FI
    Muguerza B
  • Others:

    Author, as appears in the article.: López-Fernández-sobrino R; Soliz-Rueda JR; Margalef M; Arola-Arnal A; Suárez M; Bravo FI; Muguerza B
    Department: Bioquímica i Biotecnologia
    e-ISSN: 2072-6643
    URV's Author/s: Arola Arnal, Anna / Bravo Vázquez, Francisca Isabel / MARGALEF JORNET, MARIA / Miró Martínez, Eric / Muguerza Marquínez, Maria Begoña / Soliz Rueda, Jorge Ricardo / Suárez Recio, Manuel
    Keywords: Winery by-product Shr Polyphenols Hypertension Cabernet grape variety Blood pressure
    Abstract: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Wine lees (WL) are by-products generated in the winemaking process. The aim of this study was to investigate the angiotensin-converting enzyme inhibitory (ACEi) activity, and the blood pressure (BP) lowering effect of WL from individual grape varieties. The relationship among their activities and phenolic profiles was also studied. Three WL, from Cabernet, Mazuela, and Garnacha grape varieties, were firstly selected based on their ACEi properties. Their phenolic profiles were fully characterized by UHPLC-ESI-Q-TOF-MS. Then, their potential antihypertensive effects were evaluated in spontaneously hypertensive rats (SHR). BP was recorded before and after their oral administrations (2, 4, 6, 8, 24, and 48 h) at a dose of 5 mL/kg bw. Cabernet WL (CWL) exhibited a potent antihypertensive activity, similar to that obtained with the drug Captopril. This BP-lowering effect was related to the high amount of anthocyanins and flavanols present in these lees. In addition, a potential hypotensive effect of CWL was discarded in normotensive Wistar– Kyoto rats. Finally, the ACEi and antihypertensive activities of CWL coming from a different harvest were confirmed. Our results suggest the potential of CWL for controlling arterial BP, opening the door to commercial use within the wine industry.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: franciscaisabel.bravo@urv.cat begona.muguerza@urv.cat anna.arola@urv.cat manuel.suarez@urv.cat jorgericardo.soliz@urv.cat 0 0 0
    Author identifier: 0000-0002-6468-3088 0000-0001-7384-8588 0000-0001-6529-1345 0000-0003-0122-8253
    Record's date: 2023-09-23
    Journal volume: 13
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/13/2/679
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 13 (2): 1-17
    APA: López-Fernández-sobrino R; Soliz-Rueda JR; Margalef M; Arola-Arnal A; Suárez M; Bravo FI; Muguerza B (2021). Ace inhibitory and antihypertensive activities of wine lees and relationship among bioactivity and phenolic profile. Nutrients, 13(2), 1-17. DOI: 10.3390/nu13020679
    Article's DOI: 10.3390/nu13020679
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Winery by-product
    Shr
    Polyphenols
    Hypertension
    Cabernet grape variety
    Blood pressure
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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