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Cocoa and grape seed byproducts as a source of antioxidant and anti-inflammatory proanthocyanidins - PC:2584
Cocoa and grape seed byproducts as a source of antioxidant and anti-inflammatory proanthocyanidins - PC:2584
Diposit document versioninfo:eu-repo/semantics/publishedVersion
Article's DOIhttps://doi.org/10.3390/ijms18020376
AbstractPhenolic compounds, which are secondary plant metabolites, are considered an integral part of the human diet. Physiological properties of dietary polyphenols have come to the attention in recent years. Especially, proanthocyanidins (ranging from dimers to decamers) have demonstrated potential interactions with biological systems, such as antiviral, antibacterial, molluscicidal, enzyme-inhibiting, antioxidant, and radical-scavenging properties. Agroindustry produces a considerable amount of phenolic-rich sources, and the ability of polyphenolic structures to interacts with other molecules in living organisms confers their beneficial properties. Cocoa wastes and grape seeds and skin byproducts are a source of several phenolic compounds, particularly mono-, oligo-, and polymeric proanthocyanidins. The aim of this work is to compare the phenolic composition of Theobroma cacao and Vitis vinifera grape seed extracts by high pressure liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer and equipped with an electrospray ionization interface (HPLC-ESI-QTOF-MS) and its phenolic quantitation in order to evaluate the proanthocyanidin profile. The antioxidant capacity was measured by different methods, including electron transfer and hydrogen atom transfer-based mechanisms, and total phenolic and flavan-3-ol contents were carried out by Folin-Ciocalteu and Vanillin assays. In addition, to assess the anti-inflammatory capacity, the expression of MCP-1 in human umbilical vein endothelial cells was measured.
Journal volume18
First page376
Link to the orginal sourcehttps://www.mdpi.com/1422-0067/18/2/376
Publication TypeArticle
Publication TypeArtículo
Publication TypeArticle
Repository ingest date2017-03-01
Resource size1208 kb
EntityUniversitat Rovira i Virgili
DepartmentMedicina i Cirurgia
Research groupUnitat de Recerca Biomèdica
Document URLhttp://nportal0.urv.cat:18080/fourrepo/rest/digitalobjects/DS?objectId=PC%3A2584&datastreamId=DocumentPrincipal&mime=application%2Fpdf
Document nameCocoa and grape seed byproducts as a source of antioxidant and anti-inflammatory proanthocyanidins
Source publication titleInternational Journal Of Molecular Sciences
AuthorJOVEN MARIED, JORGE; María De La Luz Cádiz-Gurrea; Isabel Borrás-Linares; Jesús Lozano-Sánchez; Salvador Fernández-Arroyo; Antonio Segura-Carretero
Publication statusarticle
Thematic AreasHealth sciences
Thematic AreasCiencias de la salud
Thematic AreasCiències de la salut
KeywordsAnti-inflammatory activity
KeywordsAntioxidant activity
Journal publication year2017
Researcher identifierN/D; N/D; N/D; N/D; N/D; N/D
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