Author, as appears in the article.: Codina H; Vieitez I; Gutierrez-Valencia A; Skouridou V; Martínez C; Patiño L; Botero-Gallego M; Trujillo-Rodríguez M; Serna-Gallego A; Muñoz-Muela E; Bobillo MM; Pérez A; Cabrera-Alvar JJ; Crespo M; O’sullivan CK; Ruiz-Mateos E; Poveda E

Department: Enginyeria Química

URV's Author/s: O'SULLIVAN, CIARA KATHLEEN

Keywords: Anti-sars-cov-2 antibodies Cytokines Sars-cov-2 Severe covid-19 Viral load

Abstract: Viral and host immune kinetics during acute COVID-19 and after remission of acute symptoms need better characterization. SARS-CoV-2 RNA, anti-SARS-CoV-2 IgA, IgM, and IgG antibodies, and proinflammatory cytokines were measured in sequential samples from hospitalized COVID-19 patients during acute infection and six months following diagnosis. Twenty four laboratory confirmed COVID-19 patients with mild/moderate and severe COVID-19 were included. Most were males (83%) with a median age of 61 years. Twenty one percent were admitted to the intensive care unit (ICU) and eight of them (33.3%) met the criteria for severe COVID-19 disease. A delay in SARS-CoV-2 levels’ decline during the first six days of follow up, and viral load persistence until month 3 were related to severe COVID-19, but not viral load levels at the diagnosis. Higher levels of anti-SARS-CoV-2 IgA, IgM, IgG and the cytokines IL-6, IL-8 and MIP-1β at the diagnosis time were related to the severe COVID-19 outcome. Higher levels of MIP-1β, IL-1β, MIP-1α and IFN-γ were observed at month 1 and 3 during mild/moderate disease, compared to severe COVID-19. IgG persisted at low levels after six months of diagnosis. In conclusion, higher concentrations of IgA, IgM, and IgG, and IL-6, IL-8 and MIP-1β are identified as early predictors of COVID-19 severity, whereas no significant association is found between baseline SARS-COV-2 viral load and COVID-19 severity.

Thematic Areas: Microbiology Microbiology (medical) Virology

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: ciara.osullivan@urv.cat

Author identifier: 0000-0002-0965-4655 0000-0003-2603-2230

Record's date: 2022-01-08

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2076-2607/9/11/2259

Papper original source: Microorganisms. 9 (11):

APA: Codina H; Vieitez I; Gutierrez-Valencia A; Skouridou V; Martínez C; Patiño L; Botero-Gallego M; Trujillo-Rodríguez M; Serna-Gallego A; Muñoz-Muela E; (2021). Elevated anti-sars-cov-2 antibodies and il-6, il-8, mip-1β, early predictors of severe covid-19. Microorganisms, 9(11), -. DOI: 10.3390/microorganisms9112259

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Article's DOI: 10.3390/microorganisms9112259

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications