Repositori institucional URV
| URV's Author/s: | SALAS SALVADÓ, JORGE; Zheng Y; Hu FB; Ruiz-Canela M; Clish CB; Dennis C; Hruby A; Liang L; Toledo E; Corella D; Ros E; Fitó M; Gómez-Gracia E; Arós F; Fiol M; Lapetra J; Serra-Majem L; Estruch R; Martínez-González MA |
| Author, as appears in the article.: | Salas-Salvado J; Zheng Y; Hu FB; Ruiz-Canela M; Clish CB; Dennis C; Hruby A; Liang L; Toledo E; Corella D; Ros E; Fitó M; Gómez-Gracia E; Arós F; Fiol M; Lapetra J; Serra-Majem L; Estruch R; Martínez-González MA |
| Author identifier: | N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D |
| Journal publication year: | 2016 |
| Publication Type: | Article |
| ISSN: | 2047-9980 |
| Abstract: | Glutamate metabolism may play a role in the pathophysiology of cardiometabolic disorders. However, there is limited evidence of an association between glutamate-related metabolites and, moreover, changes in these metabolites, and risk of cardiovascular disease (CVD).
METHODS AND RESULTS:
Plasma levels of glutamate and glutamine were measured at baseline and 1-year follow-up in a case-cohort study including 980 participants (mean age 68 years; 46% male) from the PREvención con DIeta MEDiterránea (PREDIMED) randomized trial, which assessed a Mediterranean diet intervention in the primary prevention of CVD. During median 4.8 years of follow-up, there were 229 incident CVD events (nonfatal stroke, nonfatal myocardial infarction, or CVD death). In fully adjusted models, per 1-SD, baseline glutamate was associated with 43% (95% CI: 16% to 76%) and 81% (39% to 137%) increased risk of composite CVD and stroke alone, respectively, and baseline glutamine-to-glutamate ratio with 25% (6% to 40%) and 44% (25% to 58%) decreased risk of composite CVD and stroke alone, respectively. Associations appeared linear for stroke (both Plinear trend≤0.005). Among participants with high baseline glutamate, the interventions lowered CVD risk by 37% compared to the control diet; the intervention effects were not significant when baseline glutamate was low (Pinteraction=0.02). No significant effect of the intervention on year-1 changes in metabolites was observed, and no effect of changes themselves on CVD risk was apparent.
CONCLUSIONS:
Baseline glutamate was associated with increased CVD risk, particularly stroke, and glutamine-to-glutamate ratio was associated with decreased risk. Participants with high glutamate levels may obtain greater benefits from the Mediterranean diet than those with low levels. |
| Article's DOI: | 10.1161/JAHA.116.003755 |
| Link to the original source: | https://www.ahajournals.org/doi/full/10.1161/JAHA.116.003755?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed |
| Papper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Bioquímica i Biotecnologia |
| Research group: | Alimentació, Nutrició, Creixement i Salut Mental |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Thematic Areas: | Biochemistry and technology |
| Keywords: | Glutamate Metabolism Cardiovascular Events PREDIMED |
| Entity: | Universitat Rovira i Virgili |
| Record's date: | 2016-09-19 |
| Journal volume: | 5 |
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| File | Description | Format | |
|---|---|---|---|
| DocumentPrincipal | DocumentPrincipal | application/pdf |
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