Repositori institucional URV
| Author, as appears in the article.: | Vasson, M.P. Farges, M.C. Goncalves-Mendes, N. Talvas, J. Ribalta, J. Winklhofer-Roob, B. Rock, E. Rossary, A. |
| Journal publication year: | 2013 |
| ISSN: | 1742-4933 |
| Abstract: | Background As the European population is getting older, there is growing need in scientific data on how to achieve healthy and successful aging. A decline in immune function with age is unanimously supported by many epidemiological and clinical observations, with a decrease in T-cell mediated function encompassing a large part of this alteration. In the EU-funded VITAGE project, the effects of aging on biomarkers of immune status are being studied in three European countries. According to strict inclusion/exclusion criteria, a cohort of 300 healthy male non-smoking 20¿75 years old volunteers were enrolled in France (n?=?99), Spain (n?=?100) and Austria (n?=?101). In each country, the volunteers were classified as a function of age (one age group per decade). Biomarkers of immune status were determined including delayed-type hypersensitivity tests, measurement of lymphocyte surface markers, and serum determinations of interleukin-2, complement fractions and immunoglobulins. Results There were moderate differences in the biomarkers of immune status of the VITAGE study volunteers among the three European centres. The percentage of Natural Killer (NK) cells was 156% and 142% higher in Spain as compared to France and Austria, respectively (p? |
| Article's DOI: | 10.1186/1742-4933-10-38 |
| Link to the original source: | http://www.immunityageing.com/content/10/1/38 |
| Paper version: | info:eu-repo/semantics/publishedVersion |
| licence for use: | https://creativecommons.org/licenses/by/3.0/es/ |
| Department: | Medicina i Cirurgia |
| Licence document URL: | https://repositori.urv.cat/ca/proteccio-de-dades/ |
| Entity: | Universitat Rovira i Virgili. |
| First page: | 38 |
| Last page: | 49 |
| Journal volume: | 10 |
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| DocumentPrincipal | DocumentPrincipal | application/pdf |
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