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TITLE:
Efficient algorithms for constructing D- and I-optimal exact designs for linear and non-linear models in mixture experiments - RP:3413

URV's Author/s:Torsney, Bernard
García-Camacha, Irene
Martín, Raúl
Journal publication year:2019
Publication Type:info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
Abstract:The problem of finding optimal exact designs is more challenging than that of approximate optimal designs. In the present paper, we develop two efficient algorithms to numerically construct exact designs for mixture experiments. The first is a novel approach to the well-known multiplicative algorithm based on sets of permutation points, while the second uses genetic algorithms. Using (i) linear and non-linear models, (ii) D/- and I-optimality criteria, and (iii) constraints on the ingredients, both approaches are explored through several practical problems arising in the chemical, pharmaceutical and oil industry.
Keywords:Optimal experimental design, D-optimality, I-optimality, mixture experiments, multiplicative algorithm, genetic algorithm, exact designs
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