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TITLE:
Free and controlled radical polymerization of polymers for thermoresponsive hydrogels - TFG:121
Handle: https://hdl.handle.net/20.500.11797/TFG121

Student:Espasa Valdepeñas, Anna
Language:en
Title in original language:Free and controlled radical polymerization of polymers for thermoresponsive hydrogels
Title in different languages:Free and controlled radical polymerization of polymers for thermoresponsive hydrogels
Keywords:Polimerization, NIPAAm, Hydrogels, ATRP, RP, CRP, azido initiator
Subject:Polímers
Abstract:Abstract This work has been realized in ‘Makromolekure Chemie’, the polymers research group in the University of Siegen (Germany) headed by Prof. Dr. Ulrich Jonas aided by Mrs. Petra Frank. One of the research line in this group is Surface-Attached Hydrogel Layer Systems in which all my projects had been included and some of them has biomedical aims. The first project was to study a method for the synthesis of an azido functionalized initiator, 4,4 '-azobis-(3-azidopropyl)-(4-cyanopentanamide) by reaction of two products, 4,4' -azobis (4 -cyano pentanoyl chloride) and 3 -amino-1 - azidopropane which were also synthesized in this work . The initiator, which will be examined later, intended to be reacted by free Radical Polymerization with an alkyne terminal group polymer having UCLT properties. The next study will consist of couple this UCST polymer via 'click chemistry' with a polymer LCST as might be the NIPAAm which its chemical behaviour is known for previously studies. The study of the polymerization of this monomer, NIPAAm, has been developed in this study via ATRP reactions using different solvents, initiator-catalyst systems, reactions conditions and, also, by varying the ratio of monomer to initiator. This monomer is also used to form a copolymer together with two other monomers: MAA (Methacrylic acid) and BPAAm (N-(4-benzoylphenyl ) acrylamide). This NIPAAm-MAA-BPAAm copolymer, with an approximate ratio of (85:5:10) was used as the adhesion polymer into Petri dishes and crosslinked. Subsequently, the same copolymer but with a different relationship (94 :5:1) was used and studied as a hydrogel layer, the stability of which was studied against of different solutions such as water, ethanol and two buffer solutions : Tris -HCl pH 7.5 and Borate pH: 10.
Project director:Jonas, Ulrich
Work's codirector:Frank, Petra
Department:Química Física i Inorgànica
Education area(s):Química
Entity:Universitat Rovira i Virgili (URV)
TFG credits:12
Creation date in repository:2015-02-18
Work's public defense date:2014-06-05
Academic year:2013-2014
Confidenciality:No
Subject areas:Chemistry
Access rights:info:eu-repo/semantics/openAccess
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