Ru(η6-arene) Metal-based drug the modern anticancer pharmacology

Rández Garbayo, Javier

Belongs to TFG:SerieGeneralQ collection

TITLE:

Ru(η6-arene) Metal-based drug the modern anticancer pharmacology - TFG:1367

Handle:

https://hdl.handle.net/20.500.11797/TFG1367

Student:	Rández Garbayo, Javier
Language:	en
Title in original language:	Ru(η6-arene) Metal-based drug the modern anticancer pharmacology
Title in different languages:	Ru(η6-arene) Metal-based drug the modern anticancer pharmacology
Keywords:	Ru(η6-arene), anticancer
Subject:	Química
Abstract:	Research interests are based around the development of metal complexes as potential therapeutic agents and understanding their chemistry in biological systems. One major focus currently is the development of new organometallic ruthenium complex as potential anticancer agents. [(η6-arene)(Oxalate)(PTA)Ru] and [(η6- arene)(PTA)RuCl2]1,2 compounds have clearly demonstrated that the Ru(η6-arene) can produce complex with high activity against primary and secondary tumours. It is intended to extend the structural diversity of Ru Compounds (η6-arene) with the aim of improving selectivity and activity against metastasis. The aim is to form a Ru mononuclear complex (η6-arene) through the reaction of RuCl3.xH2O with a diene as a precursor followed by reaction with a phosphine ligand or ligand chelate. Various dienes are reacted with RuCl3.xH2O in MeOH /EtOH or Acetone /H2O to form an intermediate with formula [(η6-areneRuCl2]2 followed by a reaction with PTA (1,3,5- Triaza-7-phosphateamantane).3
Project director:	Murray, Benjamin.S
Work's codirector:	Fernández Gutierrez, Maria Elena
Department:	Química Física i Inorgànica
Education area(s):	Química
Entity:	Universitat Rovira i Virgili (URV)
TFG credits:	12
Creation date in repository:	2018-01-19
Work's public defense date:	2017-06-30
Academic year:	2016-2017
Confidenciality:	No
Subject areas:	Chemistry
Access rights:	info:eu-repo/semantics/openAccess

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Type:	info:eu-repo/semantics/bachelorThesis
Títol:	Ru(η6-arene) Metal-based drug the modern anticancer pharmacology
Contributor:	Fernández Gutierrez, Maria Elena Murray, Benjamin.S
Subject:	Química Chemistry Química Química
Date:	2017-06-30
Language:	en
Creator:	Rández Garbayo, Javier
Rights:	info:eu-repo/semantics/openAccess

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