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TITLE:
Design of novel beta-blockers for the retardation of breast cancer metàstasis - TFG:2575
Handle: https://hdl.handle.net/20.500.11797/TFG2575

Student:Martí Zaragoza, Àlex
Language:en
Title in original language:Design of novel beta-blockers for the retardation of breast cancer metàstasis
Title in different languages:Design of novel beta-blockers for the retardation of breast cancer metàstasis
Keywords:Cancer, Metastasis, Beta2-blockers
Subject:Química
Abstract:The synthesis of new analogues of the beta-blocker Propranolol has been explored. According to recent studies, 2-biphenyls rather than naphthalene rings provide compounds with promising β2 -ADR inhibitor properties. The project aimed to produce new derivatives with a methyl group at different positions on the substituted phenyl ring of the biphenyl moiety. Methods for preparing the appropriate iodo-cresols were explored. Two such compounds, derived from the p-cresol and m-cresol, were then converted to the final compounds by Suzuki coupling, reaction with an epoxy tosylate and ring opening with isopropylamine. However, the final products could not be fully purified and only small amounts with a few impurities were obtained. All compounds were characterized by 1H and 13C NMR.
Project director:Wallis, John
Work's codirector:Fernández Gutiérrez, Elena
Department:Química Analítica i Química Orgànica
Education area(s):Química
Entity:Universitat Rovira i Virgili (URV)
TFG credits:12
Creation date in repository:2020-03-06
Work's public defense date:2019-06-21
Academic year:2018-2019
Confidenciality:No
Subject areas:Chemistry
Access rights:info:eu-repo/semantics/openAccess
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